What compounds target EPHX2?

BiohacksAI has identified 21 compounds that interact with EPHX2 (epoxide hydrolase 2). Top compounds include: zileuton, ebselen, isoquercetin, urb 597, quercitrin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHX2 (epoxide hydrolase 2)?

EPHX2 is epoxide hydrolase 2. It is a molecular target for 21 compounds documented in PubMed bioassay data. UniProt ID: P34913. NCBI Gene ID: 2053.

EPHX2

MOLECULAR TARGET

epoxide hydrolase 2

UniProt: P34913 NCBI Gene: 205321 compounds

EPHX2 (epoxide hydrolase 2) is targeted by 21 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHX2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	zileuton	5.04	154
2	ebselen	4.74	113
3	isoquercetin	4.50	89
4	urb 597	4.08	58
5	quercitrin	3.97	52
6	zafirlukast	3.89	48
7	phlorizin	3.78	43
8	regorafenib	3.56	34
9	hyperoside	3.56	34
10	aloe emodin	3.43	30
11	talinolol	3.30	26
12	ar9281	2.71	14
13	diphenylurea	2.30	9
14	atreleuton	2.08	7
15	13 dicyclohexylurea	2.08	7
16	triclocarban	1.79	5
17	Fulvestrant	1.39	3
18	Sorafenib	1.10	2
19	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester [Supplementary Concept]	1.10	2
20	obeticholic acid [Supplementary Concept]	0.69	1
21	Sodium Dodecyl Sulfate	0.69	1

About EPHX2 as a Drug Target

EPHX2 (epoxide hydrolase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 21 compounds with documented EPHX2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHX2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.