What compounds target FECH?

BiohacksAI has identified 30 compounds that interact with FECH (ferrochelatase). Top compounds include: gefitinib, erlotinib, cabozantinib, nilotinib, bi 2536. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FECH (ferrochelatase)?

FECH is ferrochelatase. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: P22830. NCBI Gene ID: 2235.

FECH

MOLECULAR TARGET

ferrochelatase

UniProt: P22830 NCBI Gene: 223530 compounds

FECH (ferrochelatase) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FECH

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	cabozantinib	4.39	80
4	nilotinib	4.17	64
5	bi 2536	4.01	54
6	neratinib	3.66	38
7	pelitinib	3.50	32
8	ribociclib	3.26	25
9	pacritinib	3.04	20
10	lenvatinib	3.04	20
11	azd 8055	2.89	17
12	r 406	2.83	16
13	mk 2206	2.83	16
14	crenolanib	2.71	14
15	gsk 690693	2.64	13
16	linsitinib	2.64	13
17	zotiraciclib	2.56	12
18	cp 724714	2.56	12
19	cudc 101	2.40	10
20	rigosertib	2.30	9
21	gsk 1070916	2.20	8
22	bgt 226 free base	2.20	8
23	cyc 116	2.08	7
24	mk 2461	2.08	7
25	osi 027	2.08	7
26	tucatinib	1.95	6
27	varlitinib	1.79	5
28	rabusertib	1.79	5
29	Vemurafenib	1.39	3
30	Axitinib	1.10	2

About FECH as a Drug Target

FECH (ferrochelatase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented FECH interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FECH inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.