What compounds target FGFR1?

BiohacksAI has identified 72 compounds that interact with FGFR1 (fibroblast growth factor receptor 1). Top compounds include: cabozantinib, foretinib, tozasertib, vandetanib, ponatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FGFR1 (fibroblast growth factor)?

FGFR1 is fibroblast growth factor receptor 1. It is a molecular target for 72 compounds documented in PubMed bioassay data. NCBI Gene ID: 2260.

FGFR1

MOLECULAR TARGET

fibroblast growth factor receptor 1

NCBI Gene: 226072 compounds

FGFR1 (fibroblast growth factor receptor 1) is targeted by 72 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FGFR1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	cabozantinib	4.39	80
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	ponatinib	4.26	70
6	doramapimod	4.06	57
7	semaxanib	3.93	50
8	midostaurin	3.85	46
9	brigatinib	3.81	44
10	pazopanib	3.69	39
11	nintedanib	3.61	36
12	regorafenib	3.56	34
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	linifanib	3.33	27
16	mln 8054	3.33	27
17	fexagratinib	3.33	27
18	dovitinib	3.09	21
19	jnj 7706621	3.09	21
20	at 9283	3.09	21
21	upadacitinib	3.09	21
22	lestaurtinib	3.04	20
23	lenvatinib	3.04	20
24	pf 03758309	3.00	19
25	ruboxistaurin	2.94	18
26	danusertib	2.94	18
27	orantinib	2.89	17
28	r 406	2.83	16
29	cediranib	2.83	16
30	pd 0166285	2.83	16
31	pd 173074	2.83	16
32	milciclib	2.77	15
33	infigratinib	2.77	15
34	capivasertib	2.77	15
35	erdafitinib	2.77	15
36	pha 665752	2.71	14
37	plx 4720	2.71	14
38	enmd 2076	2.71	14
39	kw 2449	2.64	13
40	tivozanib	2.64	13
41	Sorafenib	2.56	12
42	ast 487	2.56	12
43	ly 2874455	2.56	12
44	raf 265	2.48	11
45	motesanib	2.48	11
46	brivanib	2.48	11
47	pemigatinib	2.40	10
48	bms 754807	2.30	9
49	azd 1480	2.30	9
50	su 014813	2.20	8

Showing top 50 of 72 compounds. Use the BiohacksAI search to explore all FGFR1 modulators.

About FGFR1 as a Drug Target

FGFR1 (fibroblast growth factor receptor 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 72 compounds with documented FGFR1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FGFR1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.