What compounds target FGFR2?

BiohacksAI has identified 47 compounds that interact with FGFR2 (fibroblast growth factor receptor 2). Top compounds include: erlotinib, ibrutinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FGFR2 (fibroblast growth factor)?

FGFR2 is fibroblast growth factor receptor 2. It is a molecular target for 47 compounds documented in PubMed bioassay data. UniProt ID: P21802. NCBI Gene ID: 2263.

FGFR2

MOLECULAR TARGET

fibroblast growth factor receptor 2

UniProt: P21802 NCBI Gene: 226347 compounds

FGFR2 (fibroblast growth factor receptor 2) is targeted by 47 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FGFR2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	ibrutinib	4.86	128
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	ceritinib	4.19	65
8	doramapimod	4.06	57
9	midostaurin	3.85	46
10	brigatinib	3.81	44
11	pazopanib	3.69	39
12	nintedanib	3.61	36
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	mln 8054	3.33	27
16	fexagratinib	3.33	27
17	dovitinib	3.09	21
18	jnj 7706621	3.09	21
19	at 9283	3.09	21
20	lestaurtinib	3.04	20
21	lenvatinib	3.04	20
22	r 406	2.83	16
23	cediranib	2.83	16
24	pd 173074	2.83	16
25	infigratinib	2.77	15
26	erdafitinib	2.77	15
27	pha 665752	2.71	14
28	plx 4720	2.71	14
29	kw 2449	2.64	13
30	ast 487	2.56	12
31	ly 2874455	2.56	12
32	brivanib	2.48	11
33	cudc 101	2.40	10
34	pemigatinib	2.40	10
35	bms 754807	2.30	9
36	su 014813	2.20	8
37	rebastinib	2.20	8
38	futibatinib	2.20	8
39	fisogatinib	2.20	8
40	mk 2461	2.08	7
41	lucitanib	1.95	6
42	h3b 6527	1.95	6
43	osi 632	1.79	5
44	fgfr inhibitor debio 1347	1.79	5
45	Sorafenib	1.61	4
46	Axitinib	0.69	1
47	Dasatinib	0.69	1

About FGFR2 as a Drug Target

FGFR2 (fibroblast growth factor receptor 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 47 compounds with documented FGFR2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FGFR2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.