What compounds target FGFR3?

BiohacksAI has identified 44 compounds that interact with FGFR3 (fibroblast growth factor receptor 3). Top compounds include: foretinib, tozasertib, vandetanib, ponatinib, ceritinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FGFR3 (fibroblast growth factor)?

FGFR3 is fibroblast growth factor receptor 3. It is a molecular target for 44 compounds documented in PubMed bioassay data. UniProt ID: P22607. NCBI Gene ID: 2261.

FGFR3

MOLECULAR TARGET

fibroblast growth factor receptor 3

UniProt: P22607 NCBI Gene: 226144 compounds

FGFR3 (fibroblast growth factor receptor 3) is targeted by 44 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FGFR3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	vandetanib	4.30	73
4	ponatinib	4.26	70
5	ceritinib	4.19	65
6	midostaurin	3.85	46
7	brigatinib	3.81	44
8	pazopanib	3.69	39
9	nintedanib	3.61	36
10	tae 684	3.43	30
11	fedratinib	3.40	29
12	mln 8054	3.33	27
13	fexagratinib	3.33	27
14	dovitinib	3.09	21
15	jnj 7706621	3.09	21
16	at 9283	3.09	21
17	lestaurtinib	3.04	20
18	r 406	2.83	16
19	cediranib	2.83	16
20	pd 173074	2.83	16
21	infigratinib	2.77	15
22	erdafitinib	2.77	15
23	pha 665752	2.71	14
24	kw 2449	2.64	13
25	ast 487	2.56	12
26	ly 2874455	2.56	12
27	brivanib	2.48	11
28	pemigatinib	2.40	10
29	bms 754807	2.30	9
30	elliptinium	2.30	9
31	su 014813	2.20	8
32	rebastinib	2.20	8
33	futibatinib	2.20	8
34	fisogatinib	2.20	8
35	mk 2461	2.08	7
36	Sorafenib	1.95	6
37	lucitanib	1.95	6
38	h3b 6527	1.95	6
39	osi 632	1.79	5
40	fgfr inhibitor debio 1347	1.79	5
41	Axitinib	1.10	2
42	Crizotinib	1.10	2
43	Dasatinib	0.69	1
44	sp600125	0.69	1

About FGFR3 as a Drug Target

FGFR3 (fibroblast growth factor receptor 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 44 compounds with documented FGFR3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FGFR3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.