What compounds target FLT4?

BiohacksAI has identified 60 compounds that interact with FLT4 (fms related receptor tyrosine kinase 4). Top compounds include: erlotinib, cabozantinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FLT4 (fms related receptor)?

FLT4 is fms related receptor tyrosine kinase 4. It is a molecular target for 60 compounds documented in PubMed bioassay data. NCBI Gene ID: 2324.

FLT4

MOLECULAR TARGET

fms related receptor tyrosine kinase 4

NCBI Gene: 232460 compounds

FLT4 (fms related receptor tyrosine kinase 4) is targeted by 60 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FLT4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	cabozantinib	4.39	80
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	doramapimod	4.06	57
7	quizartinib	3.99	53
8	semaxanib	3.93	50
9	midostaurin	3.85	46
10	brigatinib	3.81	44
11	pazopanib	3.69	39
12	vatalanib	3.69	39
13	nintedanib	3.61	36
14	regorafenib	3.56	34
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	linifanib	3.33	27
18	mln 8054	3.33	27
19	tandutinib	3.22	24
20	dovitinib	3.09	21
21	jnj 7706621	3.09	21
22	at 9283	3.09	21
23	lestaurtinib	3.04	20
24	lenvatinib	3.04	20
25	filgotinib	3.04	20
26	danusertib	2.94	18
27	defosbarasertib	2.89	17
28	r 406	2.83	16
29	cediranib	2.83	16
30	milciclib	2.77	15
31	infigratinib	2.77	15
32	sotrastaurin	2.77	15
33	Sorafenib	2.71	14
34	pha 665752	2.71	14
35	kw 2449	2.64	13
36	tivozanib	2.64	13
37	ast 487	2.56	12
38	raf 265	2.48	11
39	motesanib	2.48	11
40	brivanib	2.48	11
41	berzosertib	2.30	9
42	su 014813	2.20	8
43	rebastinib	2.20	8
44	gsk 1070916	2.20	8
45	enzastaurin	2.08	7
46	mk 2461	2.08	7
47	cep 1347	2.08	7
48	maleimide	1.95	6
49	bastadin 7	1.95	6
50	cerdulatinib	1.95	6

Showing top 50 of 60 compounds. Use the BiohacksAI search to explore all FLT4 modulators.

About FLT4 as a Drug Target

FLT4 (fms related receptor tyrosine kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 60 compounds with documented FLT4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FLT4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.