What compounds target GAK?

BiohacksAI has identified 73 compounds that interact with GAK (cyclin G associated kinase). Top compounds include: gefitinib, erlotinib, imatinib, sb 203580, alvocidib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is GAK (cyclin G associated)?

GAK is cyclin G associated kinase. It is a molecular target for 73 compounds documented in PubMed bioassay data. UniProt ID: O14976. NCBI Gene ID: 2580.

GAK

MOLECULAR TARGET

cyclin G associated kinase

UniProt: O14976 NCBI Gene: 258073 compounds

GAK (cyclin G associated kinase) is targeted by 73 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting GAK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	sb 203580	4.92	136
5	alvocidib	4.52	91
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	ponatinib	4.26	70
9	ruxolitinib	4.23	68
10	bosutinib	4.08	58
11	bi 2536	4.01	54
12	midostaurin	3.85	46
13	silmitasertib	3.78	43
14	pazopanib	3.69	39
15	neratinib	3.66	38
16	abemaciclib	3.66	38
17	sb 202190	3.64	37
18	baricitinib	3.56	34
19	canertinib	3.53	33
20	pelitinib	3.50	32
21	bms 387032	3.47	31
22	tae 684	3.43	30
23	fedratinib	3.40	29
24	gilteritinib	3.40	29
25	linifanib	3.33	27
26	saracatinib	3.33	27
27	sgi 1776	3.26	25
28	ribociclib	3.26	25
29	tandutinib	3.22	24
30	sp 600125	3.22	24
31	alectinib	3.18	23
32	rociletinib	3.18	23
33	dacomitinib anhydrous	3.14	22
34	dovitinib	3.09	21
35	jnj 7706621	3.09	21
36	at 9283	3.09	21
37	upadacitinib	3.09	21
38	lestaurtinib	3.04	20
39	pacritinib	3.04	20
40	adavosertib	3.04	20
41	pf 03758309	3.00	19
42	ruboxistaurin	2.94	18
43	galunisertib	2.94	18
44	momelotinib	2.89	17
45	orantinib	2.89	17
46	r 406	2.83	16
47	k 252a	2.83	16
48	cediranib	2.83	16
49	milciclib	2.77	15
50	pha 665752	2.71	14

Showing top 50 of 73 compounds. Use the BiohacksAI search to explore all GAK modulators.

About GAK as a Drug Target

GAK (cyclin G associated kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 73 compounds with documented GAK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

GAK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.