GAPDH
MOLECULAR TARGETglyceraldehyde-3-phosphate dehydrogenase
GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is targeted by 24 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting GAPDH
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Azacitidine | 1.39 | 3 |
| 2 | Azacitidine | 1.39 | 3 |
| 3 | Epinephrine | 1.39 | 3 |
| 4 | Berberine | 1.10 | 2 |
| 5 | plumbagin [Supplementary Concept] | 1.10 | 2 |
| 6 | Vitamin K 3 | 1.10 | 2 |
| 7 | caffeic acid | 0.69 | 1 |
| 8 | Catechin | 0.69 | 1 |
| 9 | Rosmarinic Acid | 0.69 | 1 |
| 10 | Vitamin K 2 | 0.69 | 1 |
| 11 | Carbazilquinone | 0.69 | 1 |
| 12 | salvin [Supplementary Concept] | 0.69 | 1 |
| 13 | Dactinomycin | 0.69 | 1 |
| 14 | Dihydroxyphenylalanine | 0.69 | 1 |
| 15 | Ergosterol | 0.69 | 1 |
| 16 | Ethidium | 0.69 | 1 |
| 17 | Fusaric Acid | 0.69 | 1 |
| 18 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | 0.69 | 1 |
| 19 | Lovastatin | 0.69 | 1 |
| 20 | Methyldopa | 0.69 | 1 |
| 21 | Norepinephrine Precursor of epinephrine that is secreted by | 0.69 | 1 |
| 22 | Oxcarbazepine | 0.69 | 1 |
| 23 | Pioglitazone | 0.69 | 1 |
| 24 | streptonigrin | 0.69 | 1 |
About GAPDH as a Drug Target
GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 24 compounds with documented GAPDH interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
GAPDH inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.