What compounds target GLI3?

BiohacksAI has identified 194 compounds that interact with GLI3 (GLI family zinc finger 3). Top compounds include: Corticosterone, Estrone, Carbaryl, cycloheximide, Hexachlorophene. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is GLI3 (GLI family zinc)?

GLI3 is GLI family zinc finger 3. It is a molecular target for 194 compounds documented in PubMed bioassay data. UniProt ID: AAI13617. NCBI Gene ID: 2737.

GLI3

MOLECULAR TARGET

GLI family zinc finger 3

UniProt: AAI13617 NCBI Gene: 2737194 compounds

GLI3 (GLI family zinc finger 3) is targeted by 194 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting GLI3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Corticosterone	1.95	6
2	Estrone	1.95	6
3	Carbaryl	1.79	5
4	cycloheximide	1.79	5
5	Hexachlorophene	1.79	5
6	Pueraria	1.61	4
7	Dehydroepiandrosterone	1.61	4
8	Genistein	1.61	4
9	Methylene Blue	1.61	4
10	Progesterone	1.61	4
11	Androstenedione	1.61	4
12	Chlorhexidine	1.61	4
13	Colchicine	1.61	4
14	Danazol	1.61	4
15	Dehydroepiandrosterone	1.61	4
16	Dihydrotestosterone	1.61	4
17	Estriol	1.61	4
18	Ethinyl Estradiol	1.61	4
19	Flutamide	1.61	4
20	Levonorgestrel	1.61	4
21	Norethindrone	1.61	4
22	Norgestrel	1.61	4
23	Piperonyl Butoxide	1.61	4
24	Reserpine	1.61	4
25	Rotenone	1.61	4
26	Testosterone Propionate	1.61	4
27	propyl gallate	1.39	3
28	Vitamin	1.39	3
29	Celecoxib	1.39	3
30	Dinoprostone	1.39	3
31	Disulfiram	1.39	3
32	Finasteride	1.39	3
33	Leflunomide	1.39	3
34	Methyltestosterone	1.39	3
35	Oxymetholone	1.39	3
36	Phenoxybenzamine	1.39	3
37	Podophyllotoxin	1.39	3
38	Budesonide	1.10	2
39	Kaempferols	1.10	2
40	Losartan	1.10	2
41	Resveratrol	1.10	2
42	Warfarin	1.10	2
43	Acetaldehyde	1.10	2
44	Aripiprazole	1.10	2
45	Astemizole Antihistamine drug now withdrawn from	1.10	2
46	Bufotenin	1.10	2
47	Buspirone	1.10	2
48	Carbamide Peroxide	1.10	2
49	Cetylpyridinium Cationic bactericidal surfactant used as	1.10	2
50	Ciclopirox	1.10	2

Showing top 50 of 194 compounds. Use the BiohacksAI search to explore all GLI3 modulators.

About GLI3 as a Drug Target

GLI3 (GLI family zinc finger 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 194 compounds with documented GLI3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

GLI3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.