What compounds target GLS?

BiohacksAI has identified 30 compounds that interact with GLS (glutaminase). Top compounds include: caffeic acid, myricetin-3-O-galactopyranoside [Supplementary Concept], Resveratrol, 2-Methoxyestradiol, ag490. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is GLS (glutaminase)?

GLS is glutaminase. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: O94925. NCBI Gene ID: 2744.

GLS

MOLECULAR TARGET

glutaminase

UniProt: O94925 NCBI Gene: 274430 compounds

GLS (glutaminase) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting GLS

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	caffeic acid	0.69	1
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
3	Resveratrol	0.69	1
4	2-Methoxyestradiol	0.69	1
5	ag490	0.69	1
6	alpha-Linolenic Acid	0.69	1
7	Ampicillin Semi-synthetic derivative of penicillin that functions as	0.69	1
8	Calcimycin	0.69	1
9	cefaclor	0.69	1
10	cefatrizine	0.69	1
11	Cefixime	0.69	1
12	daph	0.69	1
13	Diazooxonorleucine	0.69	1
14	Disulfiram	0.69	1
15	Physostigmine	0.69	1
16	ethopropazine	0.69	1
17	Fenoterol	0.69	1
18	hydroxyindoleacetic acid	0.69	1
19	Hydroxyurea	0.69	1
20	Metaproterenol	0.69	1
21	methoxyhydroxyphenylglycol	0.69	1
22	Normetanephrine	0.69	1
23	Oxytetracycline	0.69	1
24	Physostigmine	0.69	1
25	piceatannol	0.69	1
26	Reserpine	0.69	1
27	Rotenone	0.69	1
28	Suramin	0.69	1
29	Tolazamide	0.69	1
30	tyrphostin 9	0.69	1

About GLS as a Drug Target

GLS (glutaminase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented GLS interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

GLS inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.