What compounds target GMNN?

BiohacksAI has identified 58 compounds that interact with GMNN (geminin DNA replication inhibitor). Top compounds include: Disulfiram, Colchicine, Rotenone, 2-Methoxyestradiol, Nocodazole Nocodazole is. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is GMNN (geminin DNA replication)?

GMNN is geminin DNA replication inhibitor. It is a molecular target for 58 compounds documented in PubMed bioassay data. UniProt ID: O75496. NCBI Gene ID: 51053.

GMNN

MOLECULAR TARGET

geminin DNA replication inhibitor

UniProt: O75496 NCBI Gene: 5105358 compounds

GMNN (geminin DNA replication inhibitor) is targeted by 58 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting GMNN

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Disulfiram	2.40	10
2	Colchicine	2.08	7
3	Rotenone	2.08	7
4	2-Methoxyestradiol	1.79	5
5	Nocodazole Nocodazole is	1.61	4
6	Astemizole Antihistamine drug now withdrawn from	1.39	3
7	Metergoline	1.39	3
8	Podophyllotoxin	1.39	3
9	triflupromazine hydrochloride	1.39	3
10	Vorinostat	1.39	3
11	Calcimycin	1.10	2
12	Dasatinib	1.10	2
13	Digitoxin	1.10	2
14	Doxazosin	1.10	2
15	Ethinyl Estradiol	1.10	2
16	Hexachlorophene	1.10	2
17	kenpaullone	1.10	2
18	Niclosamide	1.10	2
19	Reserpine	1.10	2
20	Duloxetine Hydrochloride	0.69	1
21	Oleic Acid	0.69	1
22	ag490	0.69	1
23	Azacitidine	0.69	1
24	Azacitidine	0.69	1
25	Calcifediol	0.69	1
26	Calcitriol	0.69	1
27	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	0.69	1
28	cinacalcet	0.69	1
29	Clotrimazole	0.69	1
30	Decitabine	0.69	1
31	Desogestrel	0.69	1
32	Dibucaine	0.69	1
33	Digoxin	0.69	1
34	Ethylestrenol	0.69	1
35	Ethylmaleimide	0.69	1
36	Feprazone	0.69	1
37	Flunarizine Flunarizine is	0.69	1
38	Flunarizine Flunarizine is	0.69	1
39	Fluspirilene	0.69	1
40	gedunin	0.69	1
41	Idazoxan	0.69	1
42	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
43	Loratadine	0.69	1
44	Methyldopa	0.69	1
45	Nisoldipine	0.69	1
46	Masoprocol	0.69	1
47	Ouabain	0.69	1
48	paxilline	0.69	1
49	Perphenazine	0.69	1
50	Quinestrol	0.69	1

Showing top 50 of 58 compounds. Use the BiohacksAI search to explore all GMNN modulators.

About GMNN as a Drug Target

GMNN (geminin DNA replication inhibitor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 58 compounds with documented GMNN interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

GMNN inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.