Question 1

What compounds target GPX4?

Accepted Answer

BiohacksAI has identified 25 compounds that interact with GPX4 (glutathione peroxidase 4). Top compounds include: amlexanox, cbd, obeticholic acid [Supplementary Concept], Mepentol [Supplementary Concept], Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is GPX4 (glutathione peroxidase 4)?

Accepted Answer

GPX4 is glutathione peroxidase 4. It is a molecular target for 25 compounds documented in PubMed bioassay data.  NCBI Gene ID: 2879.

#	Compound	Confidence	Active Assays
1	amlexanox	1.10	2
2	cbd	0.69	1
3	obeticholic acid [Supplementary Concept]	0.69	1
4	Mepentol [Supplementary Concept]	0.69	1
5	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
6	Vitamin	0.69	1
7	Camptothecin	0.69	1
8	candesartan cilexetil [Supplementary Concept]	0.69	1
9	cannabidiol	0.69	1
10	Cefotetan	0.69	1
11	Cephaloglycin	0.69	1
12	Cisplatin	0.69	1
13	Dipyrone	0.69	1
14	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	0.69	1
15	Ethoxyquin Antioxidant; also	0.69	1
16	gamma-Linolenic Acid	0.69	1
17	Gestrinone	0.69	1
18	Hexachlorophene	0.69	1
19	Lypressin	0.69	1
20	Methyldopa	0.69	1
21	Masoprocol	0.69	1
22	Ornipressin	0.69	1
23	stx64	0.69	1
24	Trenbolone Acetate	0.69	1
25	Triiodothyronine	0.69	1

BiohacksAI

GPX4

Compounds Targeting GPX4

About GPX4 as a Drug Target