GRIN1
MOLECULAR TARGETglutamate ionotropic receptor NMDA type subunit 1
GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) is targeted by 20 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting GRIN1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Glutamic Acid | 3.40 | 29 |
| 2 | Glutamic Acid | 3.40 | 29 |
| 3 | Glycine | 2.77 | 15 |
| 4 | pentamidine | 1.95 | 6 |
| 5 | Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of | 1.79 | 5 |
| 6 | Dextrorphan Dextro form of levorphanol. It acts as | 1.79 | 5 |
| 7 | Levorphanol | 1.79 | 5 |
| 8 | cycloserine | 1.61 | 4 |
| 9 | Aspartic Acid | 1.39 | 3 |
| 10 | eliprodil | 1.39 | 3 |
| 11 | Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as | 1.39 | 3 |
| 12 | D-Aspartic Acid | 1.10 | 2 |
| 13 | Ethidium | 1.10 | 2 |
| 14 | Kynurenic Acid | 1.10 | 2 |
| 15 | Phenformin | 0.69 | 1 |
| 16 | Carvedilol | 0.69 | 1 |
| 17 | Dextrothyroxine | 0.69 | 1 |
| 18 | Dizocilpine Maleate | 0.69 | 1 |
| 19 | Ibotenic Acid | 0.69 | 1 |
| 20 | Spermine | 0.69 | 1 |
About GRIN1 as a Drug Target
GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 20 compounds with documented GRIN1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
GRIN1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.