Question 1

What compounds target GSK3A?

Accepted Answer

BiohacksAI has identified 15 compounds that interact with GSK3A (glycogen synthase kinase 3 alpha). Top compounds include: alsterpaullone, indirubin, kenpaullone, myricetin-3-O-galactopyranoside [Supplementary Concept], Apigenin 5,7,4'-trihydroxy-flavone,. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is GSK3A (glycogen synthase kinase)?

Accepted Answer

GSK3A is glycogen synthase kinase 3 alpha. It is a molecular target for 15 compounds documented in PubMed bioassay data. UniProt ID: P49840. NCBI Gene ID: 2931.

#	Compound	Confidence	Active Assays
1	alsterpaullone	1.61	4
2	indirubin	1.39	3
3	kenpaullone	1.39	3
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.10	2
5	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
6	chrysin	0.69	1
7	fisetin	0.69	1
8	Kaempferols	0.69	1
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
10	Quercetin	0.69	1
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
12	Chlorhexidine	0.69	1
13	piceatannol	0.69	1
14	sp600125	0.69	1
15	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	0.69	1

BiohacksAI

GSK3A

Compounds Targeting GSK3A

About GSK3A as a Drug Target