What compounds target HCK?

BiohacksAI has identified 56 compounds that interact with HCK (HCK proto-oncogene, Src family tyrosine kinase). Top compounds include: gefitinib, erlotinib, ibrutinib, cabozantinib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HCK (HCK proto-oncogene, Src)?

HCK is HCK proto-oncogene, Src family tyrosine kinase. It is a molecular target for 56 compounds documented in PubMed bioassay data. UniProt ID: P08631. NCBI Gene ID: 3055.

HCK

MOLECULAR TARGET

HCK proto-oncogene, Src family tyrosine kinase

UniProt: P08631 NCBI Gene: 305556 compounds

HCK (HCK proto-oncogene, Src family tyrosine kinase) is targeted by 56 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HCK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	ibrutinib	4.86	128
4	cabozantinib	4.39	80
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	ponatinib	4.26	70
9	nilotinib	4.17	64
10	bosutinib	4.08	58
11	doramapimod	4.06	57
12	midostaurin	3.85	46
13	brigatinib	3.81	44
14	pazopanib	3.69	39
15	neratinib	3.66	38
16	nintedanib	3.61	36
17	canertinib	3.53	33
18	pelitinib	3.50	32
19	tae 684	3.43	30
20	fedratinib	3.40	29
21	gilteritinib	3.40	29
22	mln 8054	3.33	27
23	saracatinib	3.33	27
24	dabrafenib	3.30	26
25	neflamapimod	3.30	26
26	alisertib	3.30	26
27	dovitinib	3.09	21
28	at 9283	3.09	21
29	dasatinib anhydrous	3.09	21
30	lestaurtinib	3.04	20
31	ruboxistaurin	2.94	18
32	danusertib	2.94	18
33	defosbarasertib	2.89	17
34	barasertib	2.89	17
35	r 406	2.83	16
36	cediranib	2.83	16
37	milciclib	2.77	15
38	masitinib	2.77	15
39	plx 4720	2.71	14
40	kw 2449	2.64	13
41	ast 487	2.56	12
42	raf 265	2.48	11
43	motesanib	2.48	11
44	brivanib	2.48	11
45	azd 7762	2.30	9
46	su 014813	2.20	8
47	rebastinib	2.20	8
48	golvatinib	2.20	8
49	cyc 116	2.08	7
50	asp 3026	2.08	7

Showing top 50 of 56 compounds. Use the BiohacksAI search to explore all HCK modulators.

About HCK as a Drug Target

HCK (HCK proto-oncogene, Src family tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 56 compounds with documented HCK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HCK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.