HDAC5
MOLECULAR TARGEThistone deacetylase 5
HDAC5 (histone deacetylase 5) is targeted by 12 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HDAC5
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Vorinostat | 4.92 | 136 |
| 2 | trichostatic acid [Supplementary Concept] related to trichostatin | 4.23 | 68 |
| 3 | scriptaid | 2.71 | 14 |
| 4 | pictilisib | 1.61 | 4 |
| 5 | Valproic Acid | 1.61 | 4 |
| 6 | Ursolic Acid | 1.10 | 2 |
| 7 | Butyric Acid | 1.10 | 2 |
| 8 | Chlorogenic Acid | 0.69 | 1 |
| 9 | Camptothecin | 0.69 | 1 |
| 10 | Celecoxib | 0.69 | 1 |
| 11 | Daunorubicin | 0.69 | 1 |
| 12 | gamma-Aminobutyric Acid | 0.69 | 1 |
About HDAC5 as a Drug Target
HDAC5 (histone deacetylase 5) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 12 compounds with documented HDAC5 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HDAC5 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.