HDAC8
MOLECULAR TARGEThistone deacetylase 8
HDAC8 (histone deacetylase 8) is targeted by 11 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HDAC8
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Vorinostat | 5.19 | 178 |
| 2 | trichostatic acid [Supplementary Concept] related to trichostatin | 4.72 | 111 |
| 3 | scriptaid | 2.89 | 17 |
| 4 | pictilisib | 1.61 | 4 |
| 5 | Valproic Acid | 1.61 | 4 |
| 6 | Butyric Acid | 1.39 | 3 |
| 7 | Daunorubicin | 1.10 | 2 |
| 8 | Ursolic Acid | 0.69 | 1 |
| 9 | Bortezomib | 0.69 | 1 |
| 10 | Camptothecin | 0.69 | 1 |
| 11 | Celecoxib | 0.69 | 1 |
About HDAC8 as a Drug Target
HDAC8 (histone deacetylase 8) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 11 compounds with documented HDAC8 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HDAC8 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.