What compounds target HDAC9?

BiohacksAI has identified 40 compounds that interact with HDAC9 (histone deacetylase 9). Top compounds include: Vorinostat, trichostatic acid [Supplementary Concept] related to trichostatin, scriptaid, Genistein, Resveratrol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HDAC9 (histone deacetylase 9)?

HDAC9 is histone deacetylase 9. It is a molecular target for 40 compounds documented in PubMed bioassay data. UniProt ID: Q9UKV0. NCBI Gene ID: 9734.

HDAC9

MOLECULAR TARGET

histone deacetylase 9

UniProt: Q9UKV0 NCBI Gene: 973440 compounds

HDAC9 (histone deacetylase 9) is targeted by 40 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HDAC9

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Vorinostat	4.87	129
2	trichostatic acid [Supplementary Concept] related to trichostatin	4.17	64
3	scriptaid	2.71	14
4	Genistein	1.95	6
5	Resveratrol	1.95	6
6	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.95	6
7	Apigenin 5,7,4'-trihydroxy-flavone,	1.61	4
8	Pueraria	1.61	4
9	Kaempferols	1.61	4
10	Quercetin	1.61	4
11	Carboxin	1.61	4
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.61	4
13	Leflunomide	1.61	4
14	Linuron	1.61	4
15	Niclosamide	1.61	4
16	pictilisib	1.61	4
17	Valproic Acid	1.61	4
18	chrysin	1.10	2
19	Methylene Blue	1.10	2
20	amlexanox	1.10	2
21	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	1.10	2
22	Axitinib	1.10	2
23	Butyric Acid	1.10	2
24	Febuxostat	1.10	2
25	Nocodazole Nocodazole is	1.10	2
26	Chlorogenic Acid	0.69	1
27	Ursolic Acid	0.69	1
28	2-Acetylaminofluorene	0.69	1
29	Camptothecin	0.69	1
30	Celecoxib	0.69	1
31	Daunorubicin	0.69	1
32	diethylhydroxylamine	0.69	1
33	felbinac	0.69	1
34	gamma-Aminobutyric Acid	0.69	1
35	Gemfibrozil	0.69	1
36	Iodoacetamide	0.69	1
37	Niflumic Acid	0.69	1
38	Oxyphenbutazone	0.69	1
39	Riluzole	0.69	1
40	thiophanate	0.69	1

About HDAC9 as a Drug Target

HDAC9 (histone deacetylase 9) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 40 compounds with documented HDAC9 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HDAC9 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.