HIPK2
MOLECULAR TARGEThomeodomain interacting protein kinase 2
HIPK2 (homeodomain interacting protein kinase 2) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HIPK2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | alvocidib | 4.52 | 91 |
| 2 | foretinib | 4.34 | 76 |
| 3 | ruxolitinib | 4.23 | 68 |
| 4 | pi 103 | 4.17 | 64 |
| 5 | bosutinib | 4.08 | 58 |
| 6 | bi 2536 | 4.01 | 54 |
| 7 | midostaurin | 3.85 | 46 |
| 8 | abemaciclib | 3.66 | 38 |
| 9 | nintedanib | 3.61 | 36 |
| 10 | bms 387032 | 3.47 | 31 |
| 11 | tae 684 | 3.43 | 30 |
| 12 | fedratinib | 3.40 | 29 |
| 13 | dovitinib | 3.09 | 21 |
| 14 | lestaurtinib | 3.04 | 20 |
| 15 | ruboxistaurin | 2.94 | 18 |
| 16 | defosbarasertib | 2.89 | 17 |
| 17 | r 406 | 2.83 | 16 |
| 18 | pha 665752 | 2.71 | 14 |
| 19 | plx 4720 | 2.71 | 14 |
| 20 | kw 2449 | 2.64 | 13 |
| 21 | gsk 690693 | 2.64 | 13 |
| 22 | ast 487 | 2.56 | 12 |
| 23 | su 014813 | 2.20 | 8 |
| 24 | enzastaurin | 2.08 | 7 |
| 25 | Sorafenib | 1.79 | 5 |
| 26 | sp600125 | 1.10 | 2 |
| 27 | ly294002 | 0.69 | 1 |
| 28 | pictilisib | 0.69 | 1 |
About HIPK2 as a Drug Target
HIPK2 (homeodomain interacting protein kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented HIPK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HIPK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.