HPGD
MOLECULAR TARGET15-hydroxyprostaglandin dehydrogenase
HPGD (15-hydroxyprostaglandin dehydrogenase) is targeted by 25 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HPGD
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Disulfiram | 1.79 | 5 |
| 2 | Genistein | 1.61 | 4 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 1.39 | 3 |
| 4 | Carmine Coloring matter from | 1.39 | 3 |
| 5 | Sulfinpyrazone | 1.39 | 3 |
| 6 | Apigenin 5,7,4'-trihydroxy-flavone, | 1.10 | 2 |
| 7 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | 1.10 | 2 |
| 8 | Quercetin | 1.10 | 2 |
| 9 | Carbidopa | 1.10 | 2 |
| 10 | Masoprocol | 1.10 | 2 |
| 11 | pd98059 | 1.10 | 2 |
| 12 | Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. | 1.10 | 2 |
| 13 | Arachidonic Acid | 0.69 | 1 |
| 14 | Kaempferols | 0.69 | 1 |
| 15 | plumbagin [Supplementary Concept] | 0.69 | 1 |
| 16 | salvin [Supplementary Concept] | 0.69 | 1 |
| 17 | DEET | 0.69 | 1 |
| 18 | diallyl trisulfide | 0.69 | 1 |
| 19 | Ethidium | 0.69 | 1 |
| 20 | Hexachlorophene | 0.69 | 1 |
| 21 | hydroxyindoleacetic acid | 0.69 | 1 |
| 22 | Indomethacin | 0.69 | 1 |
| 23 | juglone hydroxylase [Supplementary Concept] catalyzes | 0.69 | 1 |
| 24 | Linoleic Acid | 0.69 | 1 |
| 25 | Niflumic Acid | 0.69 | 1 |
About HPGD as a Drug Target
HPGD (15-hydroxyprostaglandin dehydrogenase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 25 compounds with documented HPGD interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HPGD inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.