What compounds target HRH1?

BiohacksAI has identified 55 compounds that interact with HRH1 (histamine receptor H1). Top compounds include: Histamine, Cetirizine, Aripiprazole, Chlorpheniramine, Quetiapine Fumarate. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HRH1 (histamine receptor H1)?

HRH1 is histamine receptor H1. It is a molecular target for 55 compounds documented in PubMed bioassay data. UniProt ID: P35367. NCBI Gene ID: 3269.

HRH1

MOLECULAR TARGET

histamine receptor H1

UniProt: P35367 NCBI Gene: 326955 compounds

HRH1 (histamine receptor H1) is targeted by 55 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HRH1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Histamine	3.22	24
2	Cetirizine	2.64	13
3	Aripiprazole	2.48	11
4	Chlorpheniramine	2.40	10
5	Quetiapine Fumarate	2.30	9
6	Loratadine	2.20	8
7	Astemizole Antihistamine drug now withdrawn from	1.79	5
8	Mianserin	1.61	4
9	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.61	4
10	Hydroxyzine	1.61	4
11	Promethazine	1.61	4
12	Loxapine	1.39	3
13	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	1.10	2
14	Amoxapine	1.10	2
15	Aprindine	1.10	2
16	Cyproheptadine	1.10	2
17	Fluspirilene	1.10	2
18	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.10	2
19	Maprotiline	1.10	2
20	Nortriptyline	1.10	2
21	oxatomide [Supplementary Concept] structure;	1.10	2
22	Perphenazine	1.10	2
23	Tolterodine Tartrate	1.10	2
24	Trazodone	1.10	2
25	Acetylcarnitine	0.69	1
26	Duloxetine Hydrochloride	0.69	1
27	Fluoxetine	0.69	1
28	Sirolimus	0.69	1
29	Venlafaxine Hydrochloride	0.69	1
30	amn082	0.69	1
31	Antazoline	0.69	1
32	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
33	Cabergoline	0.69	1
34	Cinnarizine	0.69	1
35	Cyclizine	0.69	1
36	Dimethindene	0.69	1
37	Domperidone	0.69	1
38	hydroxyfasudil [Supplementary Concept]	0.69	1
39	Hyoscyamine	0.69	1
40	Idarubicin	0.69	1
41	Impromidine	0.69	1
42	lidoflazine	0.69	1
43	Meclizine	0.69	1
44	Metergoline	0.69	1
45	Methylergonovine	0.69	1
46	Methysergide	0.69	1
47	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	0.69	1
48	Oxaprozin	0.69	1
49	Penicillin G	0.69	1
50	Pergolide	0.69	1

Showing top 50 of 55 compounds. Use the BiohacksAI search to explore all HRH1 modulators.

About HRH1 as a Drug Target

HRH1 (histamine receptor H1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 55 compounds with documented HRH1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HRH1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.