What compounds target HRH2?

BiohacksAI has identified 38 compounds that interact with HRH2 (histamine receptor H2). Top compounds include: Histamine, Cimetidine, Pramipexole, Burimamide, Bromocriptine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HRH2 (histamine receptor H2)?

HRH2 is histamine receptor H2. It is a molecular target for 38 compounds documented in PubMed bioassay data. UniProt ID: P25021. NCBI Gene ID: 3274.

HRH2

MOLECULAR TARGET

histamine receptor H2

UniProt: P25021 NCBI Gene: 327438 compounds

HRH2 (histamine receptor H2) is targeted by 38 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HRH2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Histamine	3.18	23
2	Cimetidine	2.89	17
3	Pramipexole	1.79	5
4	Burimamide	1.61	4
5	Bromocriptine	1.10	2
6	Dihydroergotamine	1.10	2
7	Impromidine	1.10	2
8	Methysergide	1.10	2
9	Pergolide	1.10	2
10	Amlodipine	0.69	1
11	Fluoxetine	0.69	1
12	Mianserin	0.69	1
13	Quetiapine Fumarate	0.69	1
14	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
15	Amoxapine	0.69	1
16	Aripiprazole	0.69	1
17	Astemizole Antihistamine drug now withdrawn from	0.69	1
18	Betazole	0.69	1
19	Cabergoline	0.69	1
20	Carvedilol	0.69	1
21	Cetirizine	0.69	1
22	Chlorpheniramine	0.69	1
23	Clonidine	0.69	1
24	Crizotinib	0.69	1
25	Dexpramipexole	0.69	1
26	Dihydroergocornine	0.69	1
27	Famotidine	0.69	1
28	Hydroxyzine	0.69	1
29	Lisuride	0.69	1
30	Loratadine	0.69	1
31	Loxapine	0.69	1
32	Meclizine	0.69	1
33	Metergoline	0.69	1
34	Methylergonovine	0.69	1
35	Metiamide	0.69	1
36	Promethazine	0.69	1
37	Ranitidine	0.69	1
38	Somatostatin	0.69	1

About HRH2 as a Drug Target

HRH2 (histamine receptor H2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 38 compounds with documented HRH2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HRH2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.