HSF1
MOLECULAR TARGETheat shock factor 1
HSF1 (heat shock factor 1) is targeted by 17 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HSF1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Anisomycin | 1.79 | 5 |
| 2 | celastrol | 1.61 | 4 |
| 3 | Tubercidin | 1.61 | 4 |
| 4 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | 1.39 | 3 |
| 5 | Lamivudine | 1.10 | 2 |
| 6 | Piracetam | 0.69 | 1 |
| 7 | Quercetin | 0.69 | 1 |
| 8 | cycloheximide | 0.69 | 1 |
| 9 | gamma-Aminobutyric Acid | 0.69 | 1 |
| 10 | Homoharringtonine Semisynthetic derivative of harringtonine that acts as | 0.69 | 1 |
| 11 | Masoprocol | 0.69 | 1 |
| 12 | Phentolamine | 0.69 | 1 |
| 13 | Podophyllotoxin | 0.69 | 1 |
| 14 | Procaine | 0.69 | 1 |
| 15 | Torsemide | 0.69 | 1 |
| 16 | Tripterygium | 0.69 | 1 |
| 17 | xylose | 0.69 | 1 |
About HSF1 as a Drug Target
HSF1 (heat shock factor 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 17 compounds with documented HSF1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HSF1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.