HSP90AA1
MOLECULAR TARGETheat shock protein 90 alpha family class A member 1
HSP90AA1 (heat shock protein 90 alpha family class A member 1) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HSP90AA1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | 4.22 | 67 |
| 2 | triolimus [Supplementary Concept] | 4.16 | 63 |
| 3 | monorden | 3.09 | 21 |
| 4 | gedunin | 2.20 | 8 |
| 5 | celastrol | 2.08 | 7 |
| 6 | Novobiocin | 1.39 | 3 |
| 7 | caffeic acid | 1.10 | 2 |
| 8 | Masoprocol | 1.10 | 2 |
| 9 | Tetracycline | 1.10 | 2 |
| 10 | Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. | 1.10 | 2 |
| 11 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 0.69 | 1 |
| 12 | Quercetin | 0.69 | 1 |
| 13 | 2-Chloroadenosine 2-Chloroadenosine. | 0.69 | 1 |
| 14 | Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. | 0.69 | 1 |
| 15 | ag490 | 0.69 | 1 |
| 16 | Calcimycin | 0.69 | 1 |
| 17 | Calcitriol | 0.69 | 1 |
| 18 | Ciclopirox | 0.69 | 1 |
| 19 | Clotrimazole | 0.69 | 1 |
| 20 | cycloheximide | 0.69 | 1 |
| 21 | deguelin [Supplementary Concept] | 0.69 | 1 |
| 22 | Disulfiram | 0.69 | 1 |
| 23 | Hexachlorophene | 0.69 | 1 |
| 24 | Idarubicin | 0.69 | 1 |
| 25 | Indazoles | 0.69 | 1 |
| 26 | Miconazole | 0.69 | 1 |
| 27 | piceatannol | 0.69 | 1 |
| 28 | Nitroprusside | 0.69 | 1 |
| 29 | specioside | 0.69 | 1 |
| 30 | Wortmannin | 0.69 | 1 |
About HSP90AA1 as a Drug Target
HSP90AA1 (heat shock protein 90 alpha family class A member 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented HSP90AA1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HSP90AA1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.