What compounds target HTR1A?

BiohacksAI has identified 87 compounds that interact with HTR1A (5-hydroxytryptamine receptor 1A). Top compounds include: Buspirone, Aripiprazole, Quipazine, Quetiapine Fumarate, Pindolol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR1A (5-hydroxytryptamine receptor 1A)?

HTR1A is 5-hydroxytryptamine receptor 1A. It is a molecular target for 87 compounds documented in PubMed bioassay data. UniProt ID: P08908. NCBI Gene ID: 3350.

HTR1A

MOLECULAR TARGET

5-hydroxytryptamine receptor 1A

UniProt: P08908 NCBI Gene: 335087 compounds

HTR1A (5-hydroxytryptamine receptor 1A) is targeted by 87 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR1A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Buspirone	3.83	45
2	Aripiprazole	2.40	10
3	Quipazine	2.30	9
4	Quetiapine Fumarate	2.20	8
5	Pindolol	2.20	8
6	Lisuride	2.08	7
7	Bromocriptine	1.95	6
8	Pergolide	1.95	6
9	Sumatriptan	1.95	6
10	Yohimbine	1.95	6
11	Mianserin	1.79	5
12	Cabergoline	1.79	5
13	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.79	5
14	Metergoline	1.79	5
15	Propranolol	1.79	5
16	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.61	4
17	Alprenolol	1.39	3
18	Bufotenin	1.39	3
19	Carvedilol	1.39	3
20	Mescaline Hallucinogenic alkaloid isolated from	1.39	3
21	Phentolamine	1.39	3
22	Trazodone	1.39	3
23	Fluoxetine	1.10	2
24	Astemizole Antihistamine drug now withdrawn from	1.10	2
25	brl 15572	1.10	2
26	Cyproheptadine	1.10	2
27	Dihydroergotamine	1.10	2
28	Fluspirilene	1.10	2
29	Methysergide	1.10	2
30	nafadotride	1.10	2
31	Nebivolol	1.10	2
32	Nortriptyline	1.10	2
33	Oxprenolol	1.10	2
34	Penbutolol	1.10	2
35	Piribedil	1.10	2
36	Promethazine	1.10	2
37	Raclopride	1.10	2
38	Tamsulosin	1.10	2
39	Timolol	1.10	2
40	Duloxetine Hydrochloride	0.69	1
41	Melatonin	0.69	1
42	Acebutolol	0.69	1
43	Amoxapine	0.69	1
44	Atenolol	0.69	1
45	Benzydamine	0.69	1
46	candesartan cilexetil [Supplementary Concept]	0.69	1
47	Carteolol	0.69	1
48	Celiprolol	0.69	1
49	Chlorhexidine	0.69	1
50	Cinnarizine	0.69	1

Showing top 50 of 87 compounds. Use the BiohacksAI search to explore all HTR1A modulators.

About HTR1A as a Drug Target

HTR1A (5-hydroxytryptamine receptor 1A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 87 compounds with documented HTR1A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR1A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.