What compounds target HTR2A?

BiohacksAI has identified 117 compounds that interact with HTR2A (5-hydroxytryptamine receptor 2A). Top compounds include: Mianserin, Aripiprazole, Buspirone, Chlorhexidine, Quipazine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR2A (5-hydroxytryptamine receptor 2A)?

HTR2A is 5-hydroxytryptamine receptor 2A. It is a molecular target for 117 compounds documented in PubMed bioassay data. NCBI Gene ID: 3356.

HTR2A

MOLECULAR TARGET

5-hydroxytryptamine receptor 2A

NCBI Gene: 3356117 compounds

HTR2A (5-hydroxytryptamine receptor 2A) is targeted by 117 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR2A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Mianserin	3.09	21
2	Aripiprazole	3.04	20
3	Buspirone	2.71	14
4	Chlorhexidine	2.71	14
5	Quipazine	2.64	13
6	Astemizole Antihistamine drug now withdrawn from	2.56	12
7	Quetiapine Fumarate	2.48	11
8	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	2.48	11
9	Cabergoline	2.40	10
10	Guanfacine	2.40	10
11	Promethazine	2.40	10
12	Cyproheptadine	2.30	9
13	Sumatriptan	2.30	9
14	Psilocybin	2.20	8
15	Dihydroergotamine	2.20	8
16	Lovastatin	2.20	8
17	Mescaline Hallucinogenic alkaloid isolated from	2.20	8
18	Methylergonovine	2.20	8
19	Methysergide	2.20	8
20	Nicergoline	2.20	8
21	Oxymetazoline	2.20	8
22	Thioridazine	2.20	8
23	Bufotenin	2.08	7
24	Amoxapine	1.95	6
25	Celecoxib	1.95	6
26	Diphenhydramine	1.95	6
27	Disulfiram	1.95	6
28	Fluspirilene	1.95	6
29	Guanabenz	1.95	6
30	Hexachlorophene	1.95	6
31	Metergoline	1.95	6
32	Perphenazine	1.95	6
33	Ranitidine	1.95	6
34	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	1.95	6
35	Rotenone	1.95	6
36	Pergolide	1.79	5
37	Yohimbine	1.79	5
38	Pueraria	1.61	4
39	Fluoxetine	1.61	4
40	Melatonin	1.61	4
41	vinpocetine	1.61	4
42	Cetylpyridinium Cationic bactericidal surfactant used as	1.61	4
43	Dibucaine	1.61	4
44	Domperidone	1.61	4
45	eliprodil	1.61	4
46	Ethoxyquin Antioxidant; also	1.61	4
47	Fenofibrate	1.61	4
48	Hydroxyzine	1.61	4
49	Lithocholic Acid	1.61	4
50	Lynestrenol	1.61	4

Showing top 50 of 117 compounds. Use the BiohacksAI search to explore all HTR2A modulators.

About HTR2A as a Drug Target

HTR2A (5-hydroxytryptamine receptor 2A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 117 compounds with documented HTR2A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR2A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.