What compounds target HTR6?

BiohacksAI has identified 36 compounds that interact with HTR6 (5-hydroxytryptamine receptor 6). Top compounds include: Mianserin, Metergoline, Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent, Aripiprazole, Lisuride. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR6 (5-hydroxytryptamine receptor 6)?

HTR6 is 5-hydroxytryptamine receptor 6. It is a molecular target for 36 compounds documented in PubMed bioassay data. UniProt ID: P50406. NCBI Gene ID: 3362.

HTR6

MOLECULAR TARGET

5-hydroxytryptamine receptor 6

UniProt: P50406 NCBI Gene: 336236 compounds

HTR6 (5-hydroxytryptamine receptor 6) is targeted by 36 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR6

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Mianserin	2.30	9
2	Metergoline	2.20	8
3	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	2.08	7
4	Aripiprazole	2.08	7
5	Lisuride	2.08	7
6	Loxapine	2.08	7
7	Methysergide	2.08	7
8	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.95	6
9	Ergotamine	1.79	5
10	Amoxapine	1.61	4
11	Bromocriptine	1.39	3
12	Cyproheptadine	1.39	3
13	Nortriptyline	1.39	3
14	Pergolide	1.39	3
15	Fluoxetine	1.10	2
16	Quetiapine Fumarate	1.10	2
17	Dihydroergotamine	1.10	2
18	Dihydroergotamine	1.10	2
19	Mescaline Hallucinogenic alkaloid isolated from	1.10	2
20	Perphenazine	1.10	2
21	Sumatriptan	1.10	2
22	Amlodipine	0.69	1
23	Duloxetine Hydrochloride	0.69	1
24	Astemizole Antihistamine drug now withdrawn from	0.69	1
25	brl 15572	0.69	1
26	Bufotenin	0.69	1
27	Carvedilol	0.69	1
28	Dapsone	0.69	1
29	Fluspirilene	0.69	1
30	Harmaline	0.69	1
31	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	0.69	1
32	Hydroxyzine	0.69	1
33	Quipazine	0.69	1
34	Sorafenib	0.69	1
35	Vortioxetine	0.69	1
36	Yohimbine	0.69	1

About HTR6 as a Drug Target

HTR6 (5-hydroxytryptamine receptor 6) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 36 compounds with documented HTR6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.