What compounds target HTT?

BiohacksAI has identified 35 compounds that interact with HTT (huntingtin). Top compounds include: chrysin, kenpaullone, Pueraria, 4-Chloro-7-nitrobenzofurazan, Demeclocycline. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTT (huntingtin)?

HTT is huntingtin. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: P42858. NCBI Gene ID: 3064.

HTT

MOLECULAR TARGET

huntingtin

UniProt: P42858 NCBI Gene: 306435 compounds

HTT (huntingtin) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTT

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	chrysin	1.61	4
2	kenpaullone	1.39	3
3	Pueraria	1.10	2
4	4-Chloro-7-nitrobenzofurazan	1.10	2
5	Demeclocycline	1.10	2
6	Febuxostat	1.10	2
7	hydroxyindoleacetic acid	1.10	2
8	Miconazole	1.10	2
9	Oxytetracycline	1.10	2
10	Phenelzine	1.10	2
11	Tetracycline	1.10	2
12	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.10	2
13	Resveratrol	0.69	1
14	Vitamin	0.69	1
15	Amoxapine	0.69	1
16	Azacitidine	0.69	1
17	Azacitidine	0.69	1
18	Bromodeoxyuridine	0.69	1
19	Chlorhexidine	0.69	1
20	Dactinomycin	0.69	1
21	Daunorubicin	0.69	1
22	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	0.69	1
23	Ethidium	0.69	1
24	Fluspirilene	0.69	1
25	Harmaline	0.69	1
26	Hexachlorophene	0.69	1
27	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	0.69	1
28	Idarubicin	0.69	1
29	Idazoxan	0.69	1
30	Leflunomide	0.69	1
31	Niridazole	0.69	1
32	Oxyphenbutazone	0.69	1
33	p-Aminohippuric Acid	0.69	1
34	Promethazine	0.69	1
35	rafoxanide	0.69	1

About HTT as a Drug Target

HTT (huntingtin) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented HTT interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTT inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.