What compounds target IDH1?

BiohacksAI has identified 46 compounds that interact with IDH1 (isocitrate dehydrogenase (NADP(+)) 1). Top compounds include: licochalcone, Mometasone Furoate, Dinitrochlorobenzene, Lovastatin, Methylene Blue. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is IDH1 (isocitrate dehydrogenase (NADP(+)))?

IDH1 is isocitrate dehydrogenase (NADP(+)) 1. It is a molecular target for 46 compounds documented in PubMed bioassay data. UniProt ID: CAG38738. NCBI Gene ID: 3417.

IDH1

MOLECULAR TARGET

isocitrate dehydrogenase (NADP(+)) 1

UniProt: CAG38738 NCBI Gene: 341746 compounds

IDH1 (isocitrate dehydrogenase (NADP(+)) 1) is targeted by 46 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting IDH1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	licochalcone	1.61	4
2	Mometasone Furoate	1.39	3
3	Dinitrochlorobenzene	1.10	2
4	Lovastatin	1.10	2
5	Methylene Blue	0.69	1
6	Sertraline	0.69	1
7	Simvastatin	0.69	1
8	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
9	2-Chloroadenosine 2-Chloroadenosine.	0.69	1
10	6-Aminonicotinamide	0.69	1
11	Methotrexate	0.69	1
12	Anisomycin	0.69	1
13	Astemizole Antihistamine drug now withdrawn from	0.69	1
14	Azacitidine	0.69	1
15	Azacitidine	0.69	1
16	Azathioprine	0.69	1
17	Calcimycin	0.69	1
18	Carbazilquinone	0.69	1
19	Chlorhexidine	0.69	1
20	Ciclopirox	0.69	1
21	clofilium tosylate	0.69	1
22	colchine	0.69	1
23	cycloheximide	0.69	1
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
25	Digitoxin	0.69	1
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
27	Digoxin	0.69	1
28	Ethinyl Estradiol	0.69	1
29	Fluspirilene	0.69	1
30	Hexachlorophene	0.69	1
31	Imatinib Mesylate	0.69	1
32	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
33	Miconazole	0.69	1
34	Niclosamide	0.69	1
35	Nisoldipine	0.69	1
36	Nortriptyline	0.69	1
37	propionylpromazine hydrochloride	0.69	1
38	Quinestrol	0.69	1
39	Salmeterol Xinafoate	0.69	1
40	streptonigrin	0.69	1
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
42	Thioridazine	0.69	1
43	triflupromazine hydrochloride	0.69	1
44	Tubercidin	0.69	1
45	tyrphostin 9	0.69	1
46	vinblastine sulfate	0.69	1

About IDH1 as a Drug Target

IDH1 (isocitrate dehydrogenase (NADP(+)) 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 46 compounds with documented IDH1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

IDH1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.