What compounds target IL1B?

BiohacksAI has identified 51 compounds that interact with IL1B (interleukin 1 beta). Top compounds include: Apigenin 5,7,4'-trihydroxy-flavone,, Budesonide, Hydrocortisone, Prednisolone, alsterpaullone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is IL1B (interleukin 1 beta)?

IL1B is interleukin 1 beta. It is a molecular target for 51 compounds documented in PubMed bioassay data. UniProt ID: P01584. NCBI Gene ID: 3553.

IL1B

MOLECULAR TARGET

interleukin 1 beta

UniProt: P01584 NCBI Gene: 355351 compounds

IL1B (interleukin 1 beta) is targeted by 51 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting IL1B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
2	Budesonide	0.69	1
3	Hydrocortisone	0.69	1
4	Prednisolone	0.69	1
5	alsterpaullone	0.69	1
6	Anisomycin	0.69	1
7	Antipyrine	0.69	1
8	Astemizole Antihistamine drug now withdrawn from	0.69	1
9	Beclomethasone	0.69	1
10	Betamethasone	0.69	1
11	Biotin	0.69	1
12	Bisphenol A-Glycidyl Methacrylate	0.69	1
13	Carbazilquinone	0.69	1
14	cardamonin	0.69	1
15	Chlorhexidine	0.69	1
16	cycloheximide	0.69	1
17	Dichlororibofuranosylbenzimidazole	0.69	1
18	Diethylnitrosamine	0.69	1
19	Digitoxin	0.69	1
20	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
21	Digoxin	0.69	1
22	Dinitrochlorobenzene	0.69	1
23	Disulfiram	0.69	1
24	Ethidium	0.69	1
25	Fluocinolone Acetonide	0.69	1
26	Fluorometholone	0.69	1
27	Chlorophyll Binding Proteins	0.69	1
28	Harmaline	0.69	1
29	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	0.69	1
30	Hydrocortisone	0.69	1
31	kenpaullone	0.69	1
32	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
33	Levodopa	0.69	1
34	lidoflazine	0.69	1
35	Melengestrol Acetate	0.69	1
36	Mometasone Furoate	0.69	1
37	Nicardipine	0.69	1
38	Niclosamide	0.69	1
39	Nisoldipine	0.69	1
40	Masoprocol	0.69	1
41	Nortriptyline	0.69	1
42	Oxyphenbutazone	0.69	1
43	sp600125	0.69	1
44	Spironolactone	0.69	1
45	streptonigrin	0.69	1
46	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
47	Testosterone Propionate	0.69	1
48	triflupromazine hydrochloride	0.69	1
49	Tubercidin	0.69	1
50	tyrphostin 9	0.69	1

Showing top 50 of 51 compounds. Use the BiohacksAI search to explore all IL1B modulators.

About IL1B as a Drug Target

IL1B (interleukin 1 beta) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 51 compounds with documented IL1B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

IL1B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.