What compounds target IRAK1?

BiohacksAI has identified 42 compounds that interact with IRAK1 (interleukin 1 receptor associated kinase 1). Top compounds include: gefitinib, imatinib, alvocidib, vandetanib, ponatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is IRAK1 (interleukin 1 receptor)?

IRAK1 is interleukin 1 receptor associated kinase 1. It is a molecular target for 42 compounds documented in PubMed bioassay data. UniProt ID: P51617. NCBI Gene ID: 3654.

IRAK1

MOLECULAR TARGET

interleukin 1 receptor associated kinase 1

UniProt: P51617 NCBI Gene: 365442 compounds

IRAK1 (interleukin 1 receptor associated kinase 1) is targeted by 42 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting IRAK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	imatinib	5.47	236
3	alvocidib	4.52	91
4	vandetanib	4.30	73
5	ponatinib	4.26	70
6	ruxolitinib	4.23	68
7	bosutinib	4.08	58
8	bi 2536	4.01	54
9	quizartinib	3.99	53
10	pazopanib	3.69	39
11	neratinib	3.66	38
12	abemaciclib	3.66	38
13	nintedanib	3.61	36
14	canertinib	3.53	33
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	dabrafenib	3.30	26
18	tandutinib	3.22	24
19	dovitinib	3.09	21
20	lestaurtinib	3.04	20
21	pacritinib	3.04	20
22	filgotinib	3.04	20
23	r 406	2.83	16
24	milciclib	2.77	15
25	pha 665752	2.71	14
26	crenolanib	2.71	14
27	kw 2449	2.64	13
28	ast 487	2.56	12
29	atuveciclib	2.56	12
30	mk 5108	2.48	11
31	gsk 461364	2.40	10
32	su 014813	2.20	8
33	rebastinib	2.20	8
34	encorafenib	2.20	8
35	cyc 116	2.08	7
36	ly 3009120	2.08	7
37	bafetinib	1.95	6
38	Crizotinib	1.10	2
39	Afatinib	0.69	1
40	alsterpaullone	0.69	1
41	Axitinib	0.69	1
42	Sorafenib	0.69	1

About IRAK1 as a Drug Target

IRAK1 (interleukin 1 receptor associated kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 42 compounds with documented IRAK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

IRAK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.