What compounds target ITK?

BiohacksAI has identified 27 compounds that interact with ITK (IL2 inducible T cell kinase). Top compounds include: ibrutinib, foretinib, tozasertib, bosutinib, quizartinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ITK (IL2 inducible T)?

ITK is IL2 inducible T cell kinase. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: Q08881. NCBI Gene ID: 3702.

ITK

MOLECULAR TARGET

IL2 inducible T cell kinase

UniProt: Q08881 NCBI Gene: 370227 compounds

ITK (IL2 inducible T cell kinase) is targeted by 27 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ITK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	ibrutinib	4.86	128
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	bosutinib	4.08	58
5	quizartinib	3.99	53
6	nintedanib	3.61	36
7	canertinib	3.53	33
8	pelitinib	3.50	32
9	tae 684	3.43	30
10	fedratinib	3.40	29
11	acalabrutinib	3.22	24
12	sulfuretin	3.14	22
13	dovitinib	3.09	21
14	lestaurtinib	3.04	20
15	spebrutinib	3.04	20
16	r 406	2.83	16
17	ritlecitinib	2.77	15
18	kw 2449	2.64	13
19	ast 487	2.56	12
20	zanubrutinib	2.56	12
21	evobrutinib	2.48	11
22	su 014813	2.20	8
23	rebastinib	2.20	8
24	cerdulatinib	1.95	6
25	Axitinib	0.69	1
26	Crizotinib	0.69	1
27	bdb pf 06651600 us11111242 example 5 us9617258 example 5	0.69	1

About ITK as a Drug Target

ITK (IL2 inducible T cell kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 27 compounds with documented ITK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ITK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.