What compounds target JAK3?

BiohacksAI has identified 77 compounds that interact with JAK3 (Janus kinase 3). Top compounds include: erlotinib, ibrutinib, tofacitinib, alvocidib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is JAK3 (Janus kinase 3)?

JAK3 is Janus kinase 3. It is a molecular target for 77 compounds documented in PubMed bioassay data. UniProt ID: P52333. NCBI Gene ID: 3718.

JAK3

MOLECULAR TARGET

Janus kinase 3

UniProt: P52333 NCBI Gene: 371877 compounds

JAK3 (Janus kinase 3) is targeted by 77 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting JAK3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	ibrutinib	4.86	128
3	tofacitinib	4.65	104
4	alvocidib	4.52	91
5	tozasertib	4.33	75
6	dactolisib	4.25	69
7	ruxolitinib	4.23	68
8	palbociclib	4.22	67
9	ceritinib	4.19	65
10	bosutinib	4.08	58
11	midostaurin	3.85	46
12	pazopanib	3.69	39
13	neratinib	3.66	38
14	nintedanib	3.61	36
15	baricitinib	3.56	34
16	canertinib	3.53	33
17	pelitinib	3.50	32
18	tae 684	3.43	30
19	fedratinib	3.40	29
20	sp 600125	3.22	24
21	acalabrutinib	3.22	24
22	entrectinib	3.18	23
23	sulfuretin	3.14	22
24	dacomitinib anhydrous	3.14	22
25	dovitinib	3.09	21
26	jnj 7706621	3.09	21
27	at 9283	3.09	21
28	upadacitinib	3.09	21
29	lestaurtinib	3.04	20
30	pacritinib	3.04	20
31	filgotinib	3.04	20
32	adavosertib	3.04	20
33	spebrutinib	3.04	20
34	ruboxistaurin	2.94	18
35	momelotinib	2.89	17
36	r 406	2.83	16
37	sotrastaurin	2.77	15
38	ritlecitinib	2.77	15
39	staurosporinone	2.77	15
40	pha 665752	2.71	14
41	kw 2449	2.64	13
42	ast 487	2.56	12
43	zanubrutinib	2.56	12
44	defactinib	2.48	11
45	deucravacitinib	2.48	11
46	azd 1480	2.30	9
47	reversine	2.30	9
48	vs 5584	2.30	9
49	su 014813	2.20	8
50	decernotinib	2.20	8

Showing top 50 of 77 compounds. Use the BiohacksAI search to explore all JAK3 modulators.

About JAK3 as a Drug Target

JAK3 (Janus kinase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 77 compounds with documented JAK3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

JAK3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.