What compounds target JUN?

BiohacksAI has identified 75 compounds that interact with JUN (Jun proto-oncogene, AP-1 transcription factor subunit). Top compounds include: Colchicine, DEAD-box RNA Helicases, Thioctic Acid, Diphenhydramine, Disulfiram. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is JUN (Jun proto-oncogene, AP-1)?

JUN is Jun proto-oncogene, AP-1 transcription factor subunit. It is a molecular target for 75 compounds documented in PubMed bioassay data. UniProt ID: P05412. NCBI Gene ID: 3725.

JUN

MOLECULAR TARGET

Jun proto-oncogene, AP-1 transcription factor subunit

UniProt: P05412 NCBI Gene: 372575 compounds

JUN (Jun proto-oncogene, AP-1 transcription factor subunit) is targeted by 75 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting JUN

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Colchicine	1.61	4
2	DEAD-box RNA Helicases	1.39	3
3	Thioctic Acid	1.39	3
4	Diphenhydramine	1.39	3
5	Disulfiram	1.39	3
6	glaucarubinone	1.39	3
7	Thioctic Acid	1.39	3
8	vinblastine sulfate	1.39	3
9	egcg	1.10	2
10	Methylene Blue	1.10	2
11	Amoxapine	1.10	2
12	Cinnarizine	1.10	2
13	Clofibrate	1.10	2
14	Ethoxyquin Antioxidant; also	1.10	2
15	Fenofibrate	1.10	2
16	Lithocholic Acid	1.10	2
17	Lovastatin	1.10	2
18	Lynestrenol	1.10	2
19	Medroxyprogesterone Acetate	1.10	2
20	Vitamin K 3	1.10	2
21	Mestranol	1.10	2
22	Phenoxybenzamine	1.10	2
23	Podophyllotoxin	1.10	2
24	Promethazine	1.10	2
25	triflupromazine hydrochloride	1.10	2
26	Vincamine	1.10	2
27	Azithromycin	0.69	1
28	Budesonide	0.69	1
29	Fluoxetine	0.69	1
30	Iodine	0.69	1
31	Mianserin	0.69	1
32	Sertraline	0.69	1
33	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
34	Taurine	0.69	1
35	vinpocetine	0.69	1
36	Bupranolol	0.69	1
37	Chlormadinone Acetate	0.69	1
38	Clotrimazole	0.69	1
39	Cyproheptadine	0.69	1
40	Desoxycorticosterone	0.69	1
41	Dihydrotestosterone	0.69	1
42	Dimenhydrinate	0.69	1
43	Dimethisterone	0.69	1
44	Domperidone	0.69	1
45	eliprodil	0.69	1
46	ethopropazine hydrochloride	0.69	1
47	Ethynodiol Diacetate	0.69	1
48	Fluvoxamine	0.69	1
49	Gemfibrozil	0.69	1
50	iodoform	0.69	1

Showing top 50 of 75 compounds. Use the BiohacksAI search to explore all JUN modulators.

About JUN as a Drug Target

JUN (Jun proto-oncogene, AP-1 transcription factor subunit) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 75 compounds with documented JUN interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

JUN inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.