Question 1

What compounds target KCNH2?

Accepted Answer

BiohacksAI has identified 145 compounds that interact with KCNH2 (potassium voltage-gated channel subfamily H member 2). Top compounds include: Astemizole Antihistamine drug now withdrawn from, dofetilide, Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent, Aripiprazole, Domperidone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is KCNH2 (potassium voltage-gated channel)?

Accepted Answer

KCNH2 is potassium voltage-gated channel subfamily H member 2. It is a molecular target for 145 compounds documented in PubMed bioassay data. UniProt ID: Q12809. NCBI Gene ID: 3757.

#	Compound	Confidence	Active Assays
1	Astemizole Antihistamine drug now withdrawn from	3.64	37
2	dofetilide	3.33	27
3	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	2.77	15
4	Aripiprazole	2.64	13
5	Domperidone	2.64	13
6	Quinidine	2.64	13
7	Loratadine	2.48	11
8	Fluoxetine	2.40	10
9	Reserpine	2.40	10
10	vinpocetine	2.20	8
11	Clotrimazole	2.20	8
12	Flecainide	2.20	8
13	lidoflazine	2.20	8
14	clofilium tosylate	2.08	7
15	Fluspirilene	2.08	7
16	Vincamine	2.08	7
17	Amoxapine	1.95	6
18	Fenofibrate	1.95	6
19	Lumefantrine	1.95	6
20	Phenoxybenzamine	1.95	6
21	Duloxetine Hydrochloride	1.79	5
22	Cinnarizine	1.79	5
23	Metergoline	1.79	5
24	Nitrendipine	1.79	5
25	Ondansetron	1.79	5
26	Perphenazine	1.79	5
27	Rimonabant	1.79	5
28	Celecoxib	1.61	4
29	Dibucaine	1.61	4
30	dilazep	1.61	4
31	Flunarizine Flunarizine is	1.61	4
32	Hydroxyzine	1.61	4
33	Lovastatin	1.61	4
34	Loxapine	1.61	4
35	Maprotiline	1.61	4
36	Vitamin K 3	1.61	4
37	Nebivolol	1.61	4
38	Nicergoline	1.61	4
39	Nylidrin	1.61	4
40	oxatomide [Supplementary Concept] structure;	1.61	4
41	Phentolamine	1.61	4
42	pirenperone	1.61	4
43	Promazine	1.61	4
44	Promethazine	1.61	4
45	Salmeterol Xinafoate	1.61	4
46	Thioridazine	1.61	4
47	Toxaphene	1.61	4
48	triflupromazine hydrochloride	1.61	4
49	Oleic Acid	1.39	3
50	Quetiapine Fumarate	1.39	3

BiohacksAI

KCNH2

Compounds Targeting KCNH2

About KCNH2 as a Drug Target