What compounds target LIMK2?

BiohacksAI has identified 29 compounds that interact with LIMK2 (LIM domain kinase 2). Top compounds include: foretinib, tozasertib, pi 103, pazopanib, tae 684. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is LIMK2 (LIM domain kinase)?

LIMK2 is LIM domain kinase 2. It is a molecular target for 29 compounds documented in PubMed bioassay data. UniProt ID: P53671. NCBI Gene ID: 3985.

LIMK2

MOLECULAR TARGET

LIM domain kinase 2

UniProt: P53671 NCBI Gene: 398529 compounds

LIMK2 (LIM domain kinase 2) is targeted by 29 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting LIMK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	pi 103	4.17	64
4	pazopanib	3.69	39
5	tae 684	3.43	30
6	fedratinib	3.40	29
7	linifanib	3.33	27
8	dabrafenib	3.30	26
9	jnj 7706621	3.09	21
10	at 9283	3.09	21
11	pacritinib	3.04	20
12	danusertib	2.94	18
13	r 406	2.83	16
14	capivasertib	2.77	15
15	plx 4720	2.71	14
16	ast 487	2.56	12
17	damnacanthal	2.56	12
18	aee 788	2.30	9
19	pha 680632	2.30	9
20	rebastinib	2.20	8
21	encorafenib	2.20	8
22	gandotinib	2.20	8
23	cyc 116	2.08	7
24	asp 3026	2.08	7
25	tanzisertib	1.95	6
26	lx 7101	1.95	6
27	Crizotinib	1.10	2
28	Dasatinib	0.69	1
29	Sorafenib	0.69	1

About LIMK2 as a Drug Target

LIMK2 (LIM domain kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 29 compounds with documented LIMK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

LIMK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.