What compounds target LYN?

BiohacksAI has identified 68 compounds that interact with LYN (LYN proto-oncogene, Src family tyrosine kinase). Top compounds include: gefitinib, erlotinib, imatinib, ibrutinib, cabozantinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is LYN (LYN proto-oncogene, Src)?

LYN is LYN proto-oncogene, Src family tyrosine kinase. It is a molecular target for 68 compounds documented in PubMed bioassay data. NCBI Gene ID: 4067.

LYN

MOLECULAR TARGET

LYN proto-oncogene, Src family tyrosine kinase

NCBI Gene: 406768 compounds

LYN (LYN proto-oncogene, Src family tyrosine kinase) is targeted by 68 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting LYN

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	ibrutinib	4.86	128
5	cabozantinib	4.39	80
6	foretinib	4.34	76
7	tozasertib	4.33	75
8	vandetanib	4.30	73
9	ponatinib	4.26	70
10	ceritinib	4.19	65
11	nilotinib	4.17	64
12	bosutinib	4.08	58
13	doramapimod	4.06	57
14	quizartinib	3.99	53
15	midostaurin	3.85	46
16	brigatinib	3.81	44
17	pazopanib	3.69	39
18	neratinib	3.66	38
19	nintedanib	3.61	36
20	canertinib	3.53	33
21	pelitinib	3.50	32
22	tae 684	3.43	30
23	fedratinib	3.40	29
24	mln 8054	3.33	27
25	saracatinib	3.33	27
26	dabrafenib	3.30	26
27	neflamapimod	3.30	26
28	dovitinib	3.09	21
29	at 9283	3.09	21
30	dasatinib anhydrous	3.09	21
31	lestaurtinib	3.04	20
32	spebrutinib	3.04	20
33	danusertib	2.94	18
34	defosbarasertib	2.89	17
35	barasertib	2.89	17
36	r 406	2.83	16
37	cediranib	2.83	16
38	milciclib	2.77	15
39	infigratinib	2.77	15
40	masitinib	2.77	15
41	plx 4720	2.71	14
42	kw 2449	2.64	13
43	tivozanib	2.64	13
44	ast 487	2.56	12
45	atuveciclib	2.56	12
46	raf 265	2.48	11
47	defactinib	2.48	11
48	motesanib	2.48	11
49	cudc 101	2.40	10
50	tak 285	2.40	10

Showing top 50 of 68 compounds. Use the BiohacksAI search to explore all LYN modulators.

About LYN as a Drug Target

LYN (LYN proto-oncogene, Src family tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 68 compounds with documented LYN interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

LYN inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.