Question 1

What compounds target MAOA?

Accepted Answer

BiohacksAI has identified 33 compounds that interact with MAOA (monoamine oxidase A). Top compounds include: Iproniazid, Moclobemide, Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is, Apigenin 5,7,4'-trihydroxy-flavone,, Quercetin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is MAOA (monoamine oxidase A)?

Accepted Answer

MAOA is monoamine oxidase A. It is a molecular target for 33 compounds documented in PubMed bioassay data. UniProt ID: P21397. NCBI Gene ID: 4128.

#	Compound	Confidence	Active Assays
1	Iproniazid	4.42	82
2	Moclobemide	3.09	21
3	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	2.30	9
4	Apigenin 5,7,4'-trihydroxy-flavone,	1.95	6
5	Quercetin	1.79	5
6	Phenelzine	1.79	5
7	Genistein	1.39	3
8	Idazoxan	1.39	3
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
10	Harmaline	1.10	2
11	hispidol	1.10	2
12	Linezolid	1.10	2
13	Vitamin K 3	1.10	2
14	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1.10	2
15	chrysin	0.69	1
16	Methylene Blue	0.69	1
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
18	plumbagin [Supplementary Concept]	0.69	1
19	Sirolimus	0.69	1
20	Rutin	0.69	1
21	Aripiprazole	0.69	1
22	auraptene	0.69	1
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
24	Famotidine	0.69	1
25	Fentanyl	0.69	1
26	Guanabenz	0.69	1
27	Guanfacine	0.69	1
28	juglone hydroxylase [Supplementary Concept] catalyzes	0.69	1
29	Lynestrenol	0.69	1
30	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	0.69	1
31	pentamidine	0.69	1
32	Rilmenidine Oxazole derivative that acts as	0.69	1
33	Sorafenib	0.69	1

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MAOA

Compounds Targeting MAOA

About MAOA as a Drug Target