What compounds target MAP2K1?

BiohacksAI has identified 48 compounds that interact with MAP2K1 (mitogen-activated protein kinase kinase 1). Top compounds include: tofacitinib, foretinib, tozasertib, vandetanib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP2K1 (mitogen-activated protein kinase)?

MAP2K1 is mitogen-activated protein kinase kinase 1. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: Q02750. NCBI Gene ID: 5604.

MAP2K1

MOLECULAR TARGET

mitogen-activated protein kinase kinase 1

UniProt: Q02750 NCBI Gene: 560448 compounds

MAP2K1 (mitogen-activated protein kinase kinase 1) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP2K1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	ruxolitinib	4.23	68
6	bosutinib	4.08	58
7	neratinib	3.66	38
8	nintedanib	3.61	36
9	naphthoquinone	3.58	35
10	canertinib	3.53	33
11	pelitinib	3.50	32
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	gilteritinib	3.40	29
15	trametinib	3.22	24
16	mirdametinib	3.18	23
17	dovitinib	3.09	21
18	jnj 7706621	3.09	21
19	selumetinib	3.09	21
20	lestaurtinib	3.04	20
21	hymenialdisine	3.00	19
22	ci 1040	2.94	18
23	defosbarasertib	2.89	17
24	orantinib	2.89	17
25	r 406	2.83	16
26	k 252a	2.83	16
27	oroidin	2.77	15
28	pha 665752	2.71	14
29	plx 4720	2.71	14
30	kw 2449	2.64	13
31	linsitinib	2.64	13
32	cobimetinib	2.64	13
33	debromohymenialdisine	2.56	12
34	tak 285	2.40	10
35	azd 7762	2.30	9
36	avutometinib	2.30	9
37	binimetinib	2.30	9
38	su 014813	2.20	8
39	amg 900	2.08	7
40	cep 32496	1.95	6
41	gsk 1059615	1.95	6
42	tak 733	1.95	6
43	pd98059	1.79	5
44	Dasatinib	1.10	2
45	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	0.69	1
46	Axitinib	0.69	1
47	Sorafenib	0.69	1
48	Vemurafenib	0.69	1

About MAP2K1 as a Drug Target

MAP2K1 (mitogen-activated protein kinase kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented MAP2K1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP2K1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.