MAP4K2
MOLECULAR TARGETmitogen-activated protein kinase kinase kinase kinase 2
MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2) is targeted by 22 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting MAP4K2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Carvedilol | 1.39 | 3 |
| 2 | amn082 | 1.10 | 2 |
| 3 | Aripiprazole | 1.10 | 2 |
| 4 | Astemizole Antihistamine drug now withdrawn from | 1.10 | 2 |
| 5 | Crizotinib | 1.10 | 2 |
| 6 | Fluspirilene | 1.10 | 2 |
| 7 | Duloxetine Hydrochloride | 0.69 | 1 |
| 8 | Melatonin | 0.69 | 1 |
| 9 | alsterpaullone | 0.69 | 1 |
| 10 | Axitinib | 0.69 | 1 |
| 11 | Bumetanide | 0.69 | 1 |
| 12 | Cinnarizine | 0.69 | 1 |
| 13 | Doxazosin | 0.69 | 1 |
| 14 | Harmaline | 0.69 | 1 |
| 15 | Imatinib Mesylate | 0.69 | 1 |
| 16 | Metergoline | 0.69 | 1 |
| 17 | Oleanolic Acid | 0.69 | 1 |
| 18 | Perphenazine | 0.69 | 1 |
| 19 | sp600125 | 0.69 | 1 |
| 20 | Thioridazine | 0.69 | 1 |
| 21 | Tinidazole | 0.69 | 1 |
| 22 | triflupromazine hydrochloride | 0.69 | 1 |
About MAP4K2 as a Drug Target
MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 22 compounds with documented MAP4K2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
MAP4K2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.