What compounds target MAP4K4?

BiohacksAI has identified 51 compounds that interact with MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). Top compounds include: sb 203580, foretinib, tozasertib, vandetanib, ponatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP4K4 (mitogen-activated protein kinase)?

MAP4K4 is mitogen-activated protein kinase kinase kinase kinase 4. It is a molecular target for 51 compounds documented in PubMed bioassay data. NCBI Gene ID: 9448.

MAP4K4

MOLECULAR TARGET

mitogen-activated protein kinase kinase kinase kinase 4

NCBI Gene: 944851 compounds

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) is targeted by 51 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP4K4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	sb 203580	4.92	136
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	ponatinib	4.26	70
6	bosutinib	4.08	58
7	doramapimod	4.06	57
8	quizartinib	3.99	53
9	midostaurin	3.85	46
10	pazopanib	3.69	39
11	neratinib	3.66	38
12	abemaciclib	3.66	38
13	nintedanib	3.61	36
14	pelitinib	3.50	32
15	tae 684	3.43	30
16	gilteritinib	3.40	29
17	saracatinib	3.33	27
18	dovitinib	3.09	21
19	at 9283	3.09	21
20	lestaurtinib	3.04	20
21	pacritinib	3.04	20
22	danusertib	2.94	18
23	galunisertib	2.94	18
24	k 252a	2.83	16
25	cediranib	2.83	16
26	pf 00562271	2.77	15
27	sotrastaurin	2.77	15
28	pha 665752	2.71	14
29	plx 4720	2.71	14
30	crenolanib	2.71	14
31	kw 2449	2.64	13
32	ast 487	2.56	12
33	raf 265	2.48	11
34	motesanib	2.48	11
35	brivanib	2.48	11
36	azd 7762	2.30	9
37	aee 788	2.30	9
38	su 014813	2.20	8
39	rebastinib	2.20	8
40	gsk 1070916	2.20	8
41	y 39983	2.20	8
42	cyc 116	2.08	7
43	glesatinib	2.08	7
44	pf 03814735	1.79	5
45	ucn 01	1.79	5
46	osi 632	1.79	5
47	Sorafenib	1.39	3
48	Axitinib	1.10	2
49	hydroxyfasudil [Supplementary Concept]	1.10	2
50	alsterpaullone	0.69	1

Showing top 50 of 51 compounds. Use the BiohacksAI search to explore all MAP4K4 modulators.

About MAP4K4 as a Drug Target

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 51 compounds with documented MAP4K4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP4K4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.