Question 1

What compounds target MCL1?

Accepted Answer

BiohacksAI has identified 24 compounds that interact with MCL1 (MCL1 apoptosis regulator, BCL2 family member). Top compounds include: DEAD-box RNA Helicases, Thioctic Acid, Hexachlorophene, Thioctic Acid, Oxytetracycline. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is MCL1 (MCL1 apoptosis regulator,)?

Accepted Answer

MCL1 is MCL1 apoptosis regulator, BCL2 family member. It is a molecular target for 24 compounds documented in PubMed bioassay data. UniProt ID: AAF64255. NCBI Gene ID: 4170.

#	Compound	Confidence	Active Assays
1	DEAD-box RNA Helicases	1.61	4
2	Thioctic Acid	1.61	4
3	Hexachlorophene	1.61	4
4	Thioctic Acid	1.61	4
5	Oxytetracycline	1.39	3
6	egcg	1.10	2
7	Rosmarinic Acid	1.10	2
8	paxilline	1.10	2
9	caffeic acid	0.69	1
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
11	Methylene Blue	0.69	1
12	Oleic Acid	0.69	1
13	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
14	Aurintricarboxylic Acid	0.69	1
15	Camptothecin	0.69	1
16	dofetilide	0.69	1
17	Domperidone	0.69	1
18	Ethionamide	0.69	1
19	Metergoline	0.69	1
20	Phenoxybenzamine	0.69	1
21	Phenylbutazone	0.69	1
22	Tetracycline	0.69	1
23	Tetraethylammonium	0.69	1
24	vinblastine sulfate	0.69	1

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MCL1

Compounds Targeting MCL1

About MCL1 as a Drug Target