What compounds target MDM4?

BiohacksAI has identified 51 compounds that interact with MDM4 (MDM4 regulator of p53). Top compounds include: Digoxin, Calcimycin, cycloheximide, Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide., Niclosamide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MDM4 (MDM4 regulator of)?

MDM4 is MDM4 regulator of p53. It is a molecular target for 51 compounds documented in PubMed bioassay data. UniProt ID: O15151. NCBI Gene ID: 4194.

MDM4

MOLECULAR TARGET

MDM4 regulator of p53

UniProt: O15151 NCBI Gene: 419451 compounds

MDM4 (MDM4 regulator of p53) is targeted by 51 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MDM4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Digoxin	1.61	4
2	Calcimycin	1.39	3
3	cycloheximide	1.39	3
4	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	1.39	3
5	Niclosamide	1.39	3
6	Tubercidin	1.39	3
7	Anisomycin	1.10	2
8	Astemizole Antihistamine drug now withdrawn from	1.10	2
9	Azacitidine	1.10	2
10	Azacitidine	1.10	2
11	Chlorhexidine	1.10	2
12	Ciclopirox	1.10	2
13	Cladribine	1.10	2
14	Colchicine	1.10	2
15	colchine	1.10	2
16	Cytarabine	1.10	2
17	Demecolcine	1.10	2
18	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
19	Fluspirilene	1.10	2
20	gedunin	1.10	2
21	Hexachlorophene	1.10	2
22	lidoflazine	1.10	2
23	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.10	2
24	Nisoldipine	1.10	2
25	Nocodazole Nocodazole is	1.10	2
26	Ouabain	1.10	2
27	paxilline	1.10	2
28	Podophyllotoxin	1.10	2
29	rafoxanide	1.10	2
30	streptonigrin	1.10	2
31	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	1.10	2
32	Trifluridine	1.10	2
33	tyrphostin 9	1.10	2
34	vinblastine sulfate	1.10	2
35	Methylene Blue	0.69	1
36	Sertraline	0.69	1
37	Simvastatin	0.69	1
38	Ursolic Acid	0.69	1
39	Methotrexate	0.69	1
40	Aripiprazole	0.69	1
41	cardamonin	0.69	1
42	dihydrorotenone	0.69	1
43	Dinitrochlorobenzene	0.69	1
44	Lovastatin	0.69	1
45	Melphalan	0.69	1
46	Oxyphenbutazone	0.69	1
47	propionylpromazine hydrochloride	0.69	1
48	sp600125	0.69	1
49	Spironolactone	0.69	1
50	Thioridazine	0.69	1

Showing top 50 of 51 compounds. Use the BiohacksAI search to explore all MDM4 modulators.

About MDM4 as a Drug Target

MDM4 (MDM4 regulator of p53) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 51 compounds with documented MDM4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MDM4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.