What compounds target NFKB1?

BiohacksAI has identified 30 compounds that interact with NFKB1 (nuclear factor kappa B subunit 1). Top compounds include: Quercetin, Resveratrol, Bortezomib, Podophyllotoxin, Apigenin 5,7,4'-trihydroxy-flavone,. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NFKB1 (nuclear factor kappa)?

NFKB1 is nuclear factor kappa B subunit 1. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: P19838. NCBI Gene ID: 4790.

NFKB1

MOLECULAR TARGET

nuclear factor kappa B subunit 1

UniProt: P19838 NCBI Gene: 479030 compounds

NFKB1 (nuclear factor kappa B subunit 1) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NFKB1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Quercetin	2.20	8
2	Resveratrol	1.39	3
3	Bortezomib	1.10	2
4	Podophyllotoxin	1.10	2
5	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
6	Hydrocortisone	0.69	1
7	egcg	0.69	1
8	Kaempferols	0.69	1
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
10	Rutin	0.69	1
11	Withania	0.69	1
12	Cerulenin	0.69	1
13	Chlorpropamide	0.69	1
14	daph	0.69	1
15	Disulfiram	0.69	1
16	Hexachlorophene	0.69	1
17	Hydrocortisone	0.69	1
18	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	0.69	1
19	Lovastatin	0.69	1
20	ly294002	0.69	1
21	Promethazine	0.69	1
22	protriptyline	0.69	1
23	streptonigrin	0.69	1
24	Sulfaphenazole	0.69	1
25	tamarixetin	0.69	1
26	Triamcinolone	0.69	1
27	Trifluridine	0.69	1
28	tyrphostin 1	0.69	1
29	tyrphostin ag 1478	0.69	1
30	withaferin	0.69	1

About NFKB1 as a Drug Target

NFKB1 (nuclear factor kappa B subunit 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented NFKB1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NFKB1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.