NPC1
MOLECULAR TARGETNPC intracellular cholesterol transporter 1
NPC1 (NPC intracellular cholesterol transporter 1) is targeted by 9 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting NPC1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Niclosamide | 1.10 | 2 |
| 2 | Pueraria | 0.69 | 1 |
| 3 | Genistein | 0.69 | 1 |
| 4 | Resveratrol | 0.69 | 1 |
| 5 | amlexanox | 0.69 | 1 |
| 6 | kenpaullone | 0.69 | 1 |
| 7 | pd98059 | 0.69 | 1 |
| 8 | Riluzole | 0.69 | 1 |
| 9 | tyrphostin ag 1295 | 0.69 | 1 |
About NPC1 as a Drug Target
NPC1 (NPC intracellular cholesterol transporter 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 9 compounds with documented NPC1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
NPC1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.