What compounds target NR1H4?

BiohacksAI has identified 65 compounds that interact with NR1H4 (nuclear receptor subfamily 1 group H member 4). Top compounds include: Chenodeoxycholic Acid, obeticholic acid [Supplementary Concept], Genistein, Ursodeoxycholic Acid, Cholic Acid. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NR1H4 (nuclear receptor subfamily)?

NR1H4 is nuclear receptor subfamily 1 group H member 4. It is a molecular target for 65 compounds documented in PubMed bioassay data. UniProt ID: ADZ17382. NCBI Gene ID: 9971.

NR1H4

MOLECULAR TARGET

nuclear receptor subfamily 1 group H member 4

UniProt: ADZ17382 NCBI Gene: 997165 compounds

NR1H4 (nuclear receptor subfamily 1 group H member 4) is targeted by 65 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NR1H4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Chenodeoxycholic Acid	4.13	61
2	obeticholic acid [Supplementary Concept]	3.99	53
3	Genistein	1.95	6
4	Ursodeoxycholic Acid	1.95	6
5	Cholic Acid	1.79	5
6	Lithocholic Acid	1.79	5
7	Resveratrol	1.61	4
8	Ethidium	1.61	4
9	Ethinyl Estradiol	1.61	4
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.61	4
11	Apigenin 5,7,4'-trihydroxy-flavone,	1.39	3
12	Colchicine	1.39	3
13	Rotenone	1.39	3
14	Methylene Blue	1.10	2
15	Chlormadinone Acetate	1.10	2
16	Clotrimazole	1.10	2
17	Dactinomycin	1.10	2
18	Daunorubicin	1.10	2
19	Decitabine	1.10	2
20	Finasteride	1.10	2
21	Fulvestrant	1.10	2
22	Itraconazole	1.10	2
23	Mometasone Furoate	1.10	2
24	Podophyllotoxin	1.10	2
25	trequinsin hydrochloride	1.10	2
26	vinblastine sulfate	1.10	2
27	Atorvastatin	0.69	1
28	chrysin	0.69	1
29	Dehydroepiandrosterone	0.69	1
30	Thyroxine	0.69	1
31	Progesterone	0.69	1
32	Simvastatin	0.69	1
33	Adapalene	0.69	1
34	Methotrexate	0.69	1
35	Azacitidine	0.69	1
36	Azacitidine	0.69	1
37	Chlorhexidine	0.69	1
38	Deferasirox	0.69	1
39	Dehydroepiandrosterone	0.69	1
40	Dihydrotestosterone	0.69	1
41	Dinitrochlorobenzene	0.69	1
42	Emetine	0.69	1
43	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
44	Estramustine	0.69	1
45	Ethylestrenol	0.69	1
46	Gestrinone	0.69	1
47	Glycochenodeoxycholic Acid	0.69	1
48	Idazoxan	0.69	1
49	Imatinib Mesylate	0.69	1
50	Levonorgestrel	0.69	1

Showing top 50 of 65 compounds. Use the BiohacksAI search to explore all NR1H4 modulators.

About NR1H4 as a Drug Target

NR1H4 (nuclear receptor subfamily 1 group H member 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 65 compounds with documented NR1H4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NR1H4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.