What compounds target NR3C1?

BiohacksAI has identified 150 compounds that interact with NR3C1 (nuclear receptor subfamily 3 group C member 1). Top compounds include: Prednisolone, Hydrocortisone, Corticosterone, Hydrocortisone, Budesonide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NR3C1 (nuclear receptor subfamily)?

NR3C1 is nuclear receptor subfamily 3 group C member 1. It is a molecular target for 150 compounds documented in PubMed bioassay data. UniProt ID: P04150. NCBI Gene ID: 2908.

NR3C1

MOLECULAR TARGET

nuclear receptor subfamily 3 group C member 1

UniProt: P04150 NCBI Gene: 2908150 compounds

NR3C1 (nuclear receptor subfamily 3 group C member 1) is targeted by 150 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NR3C1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Prednisolone	2.94	18
2	Hydrocortisone	2.77	15
3	Corticosterone	2.77	15
4	Hydrocortisone	2.77	15
5	Budesonide	2.56	12
6	Triamcinolone Acetonide	2.40	10
7	Megestrol Acetate Megestrol acetate is	2.30	9
8	Methyltestosterone	2.20	8
9	Prednisone	2.20	8
10	Triamcinolone	2.20	8
11	Medroxyprogesterone Acetate	2.08	7
12	Methylprednisolone	2.08	7
13	Progesterone	1.95	6
14	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.95	6
15	Androstenedione	1.95	6
16	Azacitidine	1.95	6
17	Azacitidine	1.95	6
18	Betamethasone	1.95	6
19	Cortisone	1.95	6
20	Desoxycorticosterone	1.95	6
21	Dihydrotestosterone	1.95	6
22	Fluocinolone Acetonide	1.95	6
23	Fluorometholone	1.95	6
24	Fluoxymesterone	1.95	6
25	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	1.95	6
26	Testosterone Propionate	1.95	6
27	Beclomethasone	1.79	5
28	cycloheximide	1.79	5
29	Ethinyl Estradiol	1.79	5
30	Fludrocortisone	1.79	5
31	Flurandrenolone	1.79	5
32	Norethindrone	1.79	5
33	Dehydroepiandrosterone	1.61	4
34	Testosterone	1.61	4
35	17-alpha-Hydroxyprogesterone	1.61	4
36	Chlormadinone Acetate	1.61	4
37	Danazol	1.61	4
38	Dehydroepiandrosterone	1.61	4
39	auricularum [Supplementary Concept] combination of above three antibiotics and dexamethasone 21-phosphate; used in	1.61	4
40	Dydrogesterone	1.61	4
41	Estriol	1.61	4
42	Estrone	1.61	4
43	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	1.61	4
44	Fluocinonide	1.61	4
45	Fluprednisolone	1.61	4
46	Fulvestrant	1.61	4
47	Levonorgestrel	1.61	4
48	Medroxyprogesterone	1.61	4
49	Melengestrol Acetate	1.61	4
50	Norgestrel	1.61	4

Showing top 50 of 150 compounds. Use the BiohacksAI search to explore all NR3C1 modulators.

About NR3C1 as a Drug Target

NR3C1 (nuclear receptor subfamily 3 group C member 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 150 compounds with documented NR3C1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NR3C1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.