What compounds target NR5A1?

BiohacksAI has identified 27 compounds that interact with NR5A1 (nuclear receptor subfamily 5 group A member 1). Top compounds include: Cladribine, vinblastine sulfate, Progesterone, Gemfibrozil, Podophyllotoxin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NR5A1 (nuclear receptor subfamily)?

NR5A1 is nuclear receptor subfamily 5 group A member 1. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: Q13285. NCBI Gene ID: 2516.

NR5A1

MOLECULAR TARGET

nuclear receptor subfamily 5 group A member 1

UniProt: Q13285 NCBI Gene: 251627 compounds

NR5A1 (nuclear receptor subfamily 5 group A member 1) is targeted by 27 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NR5A1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Cladribine	1.39	3
2	vinblastine sulfate	1.39	3
3	Progesterone	1.10	2
4	Gemfibrozil	1.10	2
5	Podophyllotoxin	1.10	2
6	Triiodothyronine	1.10	2
7	Methylene Blue	0.69	1
8	Resveratrol	0.69	1
9	Aldosterone	0.69	1
10	Methotrexate	0.69	1
11	Anisomycin	0.69	1
12	Azacitidine	0.69	1
13	Azacitidine	0.69	1
14	Bromodeoxyuridine	0.69	1
15	calycosin	0.69	1
16	Cilostazol	0.69	1
17	clofilium tosylate	0.69	1
18	cycloheximide	0.69	1
19	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
20	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
21	Digoxin	0.69	1
22	dihydrorotenone	0.69	1
23	Ethidium	0.69	1
24	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
25	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
26	Tubercidin	0.69	1
27	tyrphostin 9	0.69	1

About NR5A1 as a Drug Target

NR5A1 (nuclear receptor subfamily 5 group A member 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 27 compounds with documented NR5A1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NR5A1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.