What compounds target NSD2?

BiohacksAI has identified 186 compounds that interact with NSD2 (nuclear receptor binding SET domain protein 2). Top compounds include: Dasatinib, Axitinib, Azathioprine, Bortezomib, Crizotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NSD2 (nuclear receptor binding)?

NSD2 is nuclear receptor binding SET domain protein 2. It is a molecular target for 186 compounds documented in PubMed bioassay data. NCBI Gene ID: 7468.

NSD2

MOLECULAR TARGET

nuclear receptor binding SET domain protein 2

NCBI Gene: 7468186 compounds

NSD2 (nuclear receptor binding SET domain protein 2) is targeted by 186 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NSD2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Dasatinib	2.08	7
2	Axitinib	1.95	6
3	Azathioprine	1.95	6
4	Bortezomib	1.95	6
5	Crizotinib	1.95	6
6	Disulfiram	1.95	6
7	Ouabain	1.95	6
8	Methylene Blue	1.79	5
9	Maprotiline	1.79	5
10	Atorvastatin	1.61	4
11	ag490	1.61	4
12	alpelisib	1.61	4
13	Methotrexate	1.61	4
14	Calcitriol	1.61	4
15	Chlorhexidine	1.61	4
16	Clofarabine	1.61	4
17	Colchicine	1.61	4
18	cycloheximide	1.61	4
19	Decitabine	1.61	4
20	Deferasirox	1.61	4
21	deguelin [Supplementary Concept]	1.61	4
22	Digitoxin	1.61	4
23	Digoxin	1.61	4
24	Emetine	1.61	4
25	Ethidium	1.61	4
26	Gemcitabine	1.61	4
27	Leflunomide	1.61	4
28	Melphalan	1.61	4
29	monorden	1.61	4
30	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
31	Nocodazole Nocodazole is	1.61	4
32	pictilisib	1.61	4
33	Podophyllotoxin	1.61	4
34	Proscillaridin	1.61	4
35	Sorafenib	1.61	4
36	sp600125	1.61	4
37	Thapsigargin	1.61	4
38	torin 1	1.61	4
39	trichostatic acid [Supplementary Concept] related to trichostatin	1.61	4
40	Trifluridine	1.61	4
41	Tripterygium	1.61	4
42	vinblastine sulfate	1.61	4
43	Vincristine	1.61	4
44	withaferin	1.61	4
45	Daunorubicin	1.39	3
46	Dexrazoxane	1.39	3
47	Ethinyl Estradiol	1.39	3
48	Lovastatin	1.39	3
49	Apigenin 5,7,4'-trihydroxy-flavone,	1.10	2
50	Berberine	1.10	2

Showing top 50 of 186 compounds. Use the BiohacksAI search to explore all NSD2 modulators.

About NSD2 as a Drug Target

NSD2 (nuclear receptor binding SET domain protein 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 186 compounds with documented NSD2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NSD2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.