What compounds target NTMT1?

BiohacksAI has identified 75 compounds that interact with NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). Top compounds include: Crizotinib, tyrphostin ag 1478, Iodoacetamide, Adenosine, amlexanox. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase)?

NTMT1 is N-terminal Xaa-Pro-Lys N-methyltransferase 1. It is a molecular target for 75 compounds documented in PubMed bioassay data. UniProt ID: Q9BV86. NCBI Gene ID: 28989.

NTMT1

MOLECULAR TARGET

N-terminal Xaa-Pro-Lys N-methyltransferase 1

UniProt: Q9BV86 NCBI Gene: 2898975 compounds

NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1) is targeted by 75 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NTMT1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Crizotinib	2.40	10
2	tyrphostin ag 1478	2.20	8
3	Iodoacetamide	2.08	7
4	Adenosine	1.95	6
5	amlexanox	1.95	6
6	Dasatinib	1.95	6
7	Disulfiram	1.95	6
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.95	6
9	Oseltamivir	1.95	6
10	piceatannol	1.95	6
11	Methylene Blue	1.61	4
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.61	4
13	Epinephrine	1.61	4
14	Ethylestrenol	1.61	4
15	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	1.61	4
16	ly294002	1.61	4
17	Methyldopa	1.61	4
18	mg624	1.61	4
19	Cisplatin	1.39	3
20	Apigenin 5,7,4'-trihydroxy-flavone,	1.10	2
21	Atorvastatin	1.10	2
22	caffeic acid	1.10	2
23	Pueraria	1.10	2
24	fisetin	1.10	2
25	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
26	Minocycline	1.10	2
27	Quercetin	1.10	2
28	Resveratrol	1.10	2
29	2-Methoxyestradiol	1.10	2
30	Afatinib	1.10	2
31	Methotrexate	1.10	2
32	Aurintricarboxylic Acid	1.10	2
33	Bumetanide	1.10	2
34	Calcimycin	1.10	2
35	Camptothecin	1.10	2
36	Cefazolin	1.10	2
37	celastrol	1.10	2
38	Chlorhexidine	1.10	2
39	Demeclocycline	1.10	2
40	Dequalinium	1.10	2
41	Diamide	1.10	2
42	Diiodotyrosine	1.10	2
43	Dimethylphenylpiperazinium Iodide	1.10	2
44	Doxazosin	1.10	2
45	Estramustine	1.10	2
46	Ethidium	1.10	2
47	Ethinyl Estradiol	1.10	2
48	ethopropazine hydrochloride	1.10	2
49	Hexachlorophene	1.10	2
50	hydroxyindoleacetic acid	1.10	2

Showing top 50 of 75 compounds. Use the BiohacksAI search to explore all NTMT1 modulators.

About NTMT1 as a Drug Target

NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 75 compounds with documented NTMT1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NTMT1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.